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NSC319726

structure in first source

Also Known As:

ZMC1 compound

Networked: 4 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - NSC319726: 4

Experts

1.	Berkel, Caglar: 1 article (08/2020)
2.	Cacan, Ercan: 1 article (08/2020)
3.	Bos, Pieter H: 1 article (01/2018)
4.	Carpizo, Darren R: 1 article (01/2018)
5.	Krishnamoorthy, Lakshmi: 1 article (01/2018)
6.	Lo, Donald C: 1 article (01/2018)
7.	Pagano, Nen C: 1 article (01/2018)
8.	Quartararo, Christine E: 1 article (01/2018)
9.	Reznik, Eduard: 1 article (01/2018)
10.	Shimada, Kenichi: 1 article (01/2018)

Related Diseases

1.	Ovarian Neoplasms (Ovarian Cancer) 01/01/2015 - "This study aimed to explore the molecular mechanisms of NSC319726 in ovarian cancer by bioinformatics analyses. " 01/01/2015 - "NSC319726 may play an efficient role against ovarian cancer via targeting genes, such as RPS6KA6, BCL6, FOXO3, CCNB1, and CDC20, which are involved in oocyte meiosis pathway." 01/01/2015 - "Role of NSC319726 in ovarian cancer based on the bioinformatics analyses."
2.	Candidiasis (Moniliasis) 12/05/2017 - "The minimal in vitro toxicity of lead optimized NSC319726 and its reasonable inhibitory activity against pathogens suggest advancing this compound to in vivo toxicity testing and protection studies against candidiasis."
3.	Neoplasms (Cancer) 12/05/2017 - "As NSC319726 was first shown to have anti-cancer activity, its affects against human pathogenic fungi establish NSC319726 as a repurposed, off-patent compound that has potential antifungal activity. " 08/01/2020 - "Carboplatin and NSC319726 treatments resulted in slightly decreased DYNLL1 expression and DYNLL1 levels were decreased in the course of cancer progression in OC epithelial cells. "
4.	Glioblastoma (Glioblastoma Multiforme) 01/01/2018 - "Here, we report that the compound NSC319726 binds copper to induce oxidative stress and arrest glioblastoma-patient-derived cells at picomolar concentrations. "
5.	Hypoxia (Hypoxemia) 01/01/2018 - "We generated and validated pharmacogenomic predictions: copper toxicity was substantially inhibited by hypoxia, through an hypoxia-inducible-factor-1α-dependent pathway; copper-bound NSC319726 induced the generation of reactive oxygen species and depletion of deoxyribosyl purines, resulting in cell-cycle arrest. "

Related Drugs and Biologics

1.	Reactive Oxygen Species (Oxygen Radicals)
2.	Carboplatin (JM8)
3.	Purines
4.	Copper