HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

MC1742

a histone deacetylase inhibitor with antineoplastic activity; structure in first source

Also Known As:

5-((4-((1,1'-biphenyl)-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl)thio)-N-hydroxypentanamide

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Hydroxylamines: 16
    - Hydroxamic Acids: 239
      - MC1742: 2
- Carboxylic Acids: 973
  - Hydroxy Acids: 94
    - Hydroxamic Acids: 239
      - MC1742: 2
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - Pyrimidinones: 71
      - MC1742: 2

Experts

1.	Mai, Antonello: 2 articles (03/2022 - 05/2015)
2.	Rotili, Dante: 2 articles (03/2022 - 05/2015)
3.	Boissavy, Tom: 1 article (03/2022)
4.	Gissot, Mathieu: 1 article (03/2022)
5.	Mouveaux, Thomas: 1 article (03/2022)
6.	Pierrot, Christine: 1 article (03/2022)
7.	Roger, Emmanuel: 1 article (03/2022)
8.	Avnet, Sofia: 1 article (05/2015)
9.	Baldini, Nicola: 1 article (05/2015)
10.	Di Pompo, Gemma: 1 article (05/2015)

Related Diseases

1.	Osteosarcoma (Osteogenic Sarcoma) 05/14/2015 - "When tested in human osteosarcoma, rhabdomyosarcoma, and Ewing's sarcoma stem cells, the new HDACi MC1742 (1) and MC2625 (2) increased acetyl-H3 and acetyl-tubulin levels and inhibited CSC growth by apoptosis induction. "
2.	Ewing Sarcoma (Sarcoma, Ewing) 05/14/2015 - "When tested in human osteosarcoma, rhabdomyosarcoma, and Ewing's sarcoma stem cells, the new HDACi MC1742 (1) and MC2625 (2) increased acetyl-H3 and acetyl-tubulin levels and inhibited CSC growth by apoptosis induction. "
3.	Rhabdomyosarcoma 05/14/2015 - "When tested in human osteosarcoma, rhabdomyosarcoma, and Ewing's sarcoma stem cells, the new HDACi MC1742 (1) and MC2625 (2) increased acetyl-H3 and acetyl-tubulin levels and inhibited CSC growth by apoptosis induction. "
4.	Acute Disease 03/01/2022 - "MC1742 was active at inhibiting the growth of the parasite in vitro but also at preventing the consequences of the acute disease in vivo. "

Related Drugs and Biologics

1.	Tubulin
2.	MC2625