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MRT-92

antineoplastic; structure in first source

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amidines: 14
  - Guanidines: 29
    - MRT-92: 1

Experts

1.	Bertoni, Francesco: 1 article (01/2021)
2.	Bond, Adam G: 1 article (01/2021)
3.	Carrassa, Laura: 1 article (01/2021)
4.	Ciulli, Alessio: 1 article (01/2021)
5.	Fernandez-Zapico, Martin E: 1 article (01/2021)
6.	Gagliardi, Sinforosa: 1 article (01/2021)
7.	Gaudio, Eugenio: 1 article (01/2021)
8.	Makukhin, Nikolai: 1 article (01/2021)
9.	Manetti, Fabrizio: 1 article (01/2021)
10.	Migliorini, Francesca: 1 article (01/2021)

Related Diseases

1.

Melanoma (Melanoma, Malignant)

01/01/2021 - "Combination of MRT-92 and MZ1 strongly potentiates the antitumor effect of either drug as single agents in an orthotopic melanoma model. "
01/01/2021 - "Further, we show that combined targeting of canonical HH/GLI pathway with the SMO inhibitor MRT-92 and of the SOX2-BRD4 complex using a potent Proteolysis Targeted Chimeras (PROTACs)-derived BRD4 degrader (MZ1), yields a synergistic anti-proliferative effect in melanoma cells independently of their BRAF, NRAS, and NF1 mutational status, with complete abrogation of GLI1 expression. "

Related Drugs and Biologics

1.	Proteolysis Targeting Chimera