A-484954

eEF2K inhibitor; structure in first source

Also Known As:

7-amino-1-cyclopropyl-3-ethil-2,4-dioxo-1,2,3,4-tetrahydropyrido(2,3-d)-pyrimidine-6-carboxamide; 7-amino-1-cyclopropyl-3-ethyl-2,4-dioxo-1,2,3,4-tetrahydropyrido(2,3-d) pyrimidine-6-carboxamide; A484954

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - A-484954: 2
  - Pyridines: 88
    - A-484954: 2

Experts

1.	Kameshima, Satoshi: 1 article (05/2015)
2.	Kazama, Kyosuke: 1 article (05/2015)
3.	Okada, Muneyoshi: 1 article (05/2015)
4.	Yamawaki, Hideyuki: 1 article (05/2015)
5.	Bui, Mai-Ha: 1 article (12/2011)
6.	Chen, Zehan: 1 article (12/2011)
7.	Donnelly, Jennifer B: 1 article (12/2011)
8.	Glaser, Keith B: 1 article (12/2011)
9.	Gopalakrishnan, Sujatha M: 1 article (12/2011)
10.	Johnson, Eric F: 1 article (12/2011)

Related Diseases

1.	Neoplasms (Cancer) 12/23/2011 - "Both A-484954 and eEF2K siRNA inhibited eEF2K and reduced eEF2 phosphorylation with little effect on cancer cell growth. " 12/23/2011 - "Like siRNA, A-484954 had little effect on cancer cell growth. "
2.	Hypertrophy 05/15/2015 - "It was revealed that A-484954 inhibited MCT-induced PA hypertrophy and fibrosis but not impairment of endothelium-dependent and -independent relaxation. "
3.	Fibrosis (Cirrhosis) 05/15/2015 - "It was revealed that A-484954 inhibited MCT-induced PA hypertrophy and fibrosis but not impairment of endothelium-dependent and -independent relaxation. "

Related Drugs and Biologics

1.	Small Interfering RNA (siRNA)