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VU0468809

a dual phospholipase D1 and D2 antagonist with antiviral activity; structure in first source

Also Known As:

ML395; N-(2-(4-oxo-1-pyridin-3-ylmethyl)-1,3,8-triazaspiro(4.5)decan-8-yl)-2-naphthamide

Networked: 1 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Spiro Compounds: 2
      - VU0468809: 1
Polycyclic Compounds: 6
- Spiro Compounds: 2
  - VU0468809: 1
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - Imidazolidines: 39
        VU0468809: 1

Experts

1.	Brown, H Alex: 1 article (12/2014)
2.	Daniels, J Scott: 1 article (12/2014)
3.	Lindsley, Craig W: 1 article (12/2014)
4.	Locuson, Charles W: 1 article (12/2014)
5.	Morrison, Ryan D: 1 article (12/2014)
6.	O'Reilly, Matthew C: 1 article (12/2014)
7.	Oguin, Thomas H: 1 article (12/2014)
8.	Scott, Sarah A: 1 article (12/2014)
9.	Thomas, Paul G: 1 article (12/2014)

Related Diseases

1.

Human Influenza (Influenza)

12/01/2014 - "Discovery of a highly selective PLD2 inhibitor (ML395): a new probe with improved physiochemical properties and broad-spectrum antiviral activity against influenza strains."
12/01/2014 - "Moreover, ML395 possesses an attractive in vitro DMPK profile, improved physiochemical properties, ancillary pharmacology (Eurofins Panel) cleaner than any other reported PLD inhibitor, and has been found to possess interesting activity as an antiviral agent in cellular assays against a range of influenza strains (H1, H3, H5 and H7)."

Related Drugs and Biologics

1.	Antiviral Agents (Antivirals)
2.	1-dodecylpyridoxal (PLD)