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centrinone

a polo-like kinase 4 inhibitor; structure in first source

Also Known As:

LCR-263

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - centrinone: 4
Organic Chemicals: 133
- Sulfur Compounds: 278
  - Sulfones: 534
    - centrinone: 4

Experts

1.	Beck, James F: 1 article (11/2020)
2.	Becker, Sabine: 1 article (11/2020)
3.	Kerschner-Morales, Sophie L: 1 article (11/2020)
4.	Kühne, Marie: 1 article (11/2020)
5.	Sonnemann, Jürgen: 1 article (11/2020)
6.	Anzola, John V: 1 article (06/2015)
7.	Davis, Robert L: 1 article (06/2015)
8.	Desai, Arshad: 1 article (06/2015)
9.	Gahman, Timothy C: 1 article (06/2015)
10.	Hsia, Judy E: 1 article (06/2015)

Related Diseases

1.	Carcinogenesis 08/15/2022 - "Our data demonstrated that Il17ra(T779A)-KI and Il17rc-KO prevent the development of psoriasis and tumorigenesis in the skin, while the topical administration of centrinone does not have any effect."
2.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/01/2022 - "Effects of the PLK4 inhibitor Centrinone on the biological behaviors of acute myeloid leukemia cell lines."
3.	Ewing Sarcoma (Sarcoma, Ewing) 11/01/2020 - "CFI-400945 and centrinone elicited cell death in p53 wild-type and mutant Ewing's sarcoma cells. " 11/01/2020 - "CFI-400945 and centrinone were tested in three Ewing's sarcoma cell lines with different TP53 status. " 11/01/2020 - "Anticancer effects of the PLK4 inhibitors CFI-400945 and centrinone in Ewing's sarcoma cells."
4.	Psoriasis (Pustulosis Palmaris et Plantaris) 08/15/2022 - "Defect of IL17 Signaling, but Not Centrinone, Inhibits the Development of Psoriasis and Skin Papilloma in Mouse Models." 08/15/2022 - "Our data demonstrated that Il17ra(T779A)-KI and Il17rc-KO prevent the development of psoriasis and tumorigenesis in the skin, while the topical administration of centrinone does not have any effect."
5.	Papilloma (Papillomatosis) 08/15/2022 - "Defect of IL17 Signaling, but Not Centrinone, Inhibits the Development of Psoriasis and Skin Papilloma in Mouse Models."

Related Drugs and Biologics

1.	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)
2.	Phosphotransferases (Kinase)
3.	2- (3- (4- ((2,6- dimethylmorpholino)methyl)styryl)- 1H- indazol- 6- yl)- 5'- methoxyspiro(cyclopropane- 1,3'- indolin)- 2'- one

Related Therapies and Procedures

1.	Topical Administration