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PRN694

an inhibitor of both interleukin-2-inducible T-cell kinase and resting lymphocyte kinase; structure in first source

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzimidazoles: 245
      - PRN694: 2

Experts

1.	Bradshaw, J Michael: 2 articles (01/2018 - 11/2015)
2.	Funk, Jens Oliver: 2 articles (01/2018 - 11/2015)
3.	Haberstock-Debic, Helena: 2 articles (01/2018 - 11/2015)
4.	Fuhriman, Jessica M: 1 article (01/2018)
5.	Marinkovich, M Peter: 1 article (01/2018)
6.	Winge, Mårten C G: 1 article (01/2018)
7.	Berg, Leslie J: 1 article (11/2015)
8.	Cho, Hyoung-Soo: 1 article (11/2015)
9.	Hill, Ronald J: 1 article (11/2015)
10.	Owens, Timothy D: 1 article (11/2015)

Related Diseases

1.	Disease Progression 11/15/2015 - "Using a T cell adoptive transfer model of colitis, we find that in vivo administration of PRN694 markedly reduces disease progression, T cell infiltration into the intestinal lamina propria, and IFN-γ production by colitogenic CD4(+) T cells. "
2.	Skin Diseases (Skin Disease) 01/01/2018 - "ITK and RLK Inhibitor PRN694 Improves Skin Disease in Two Mouse Models of Psoriasis."
3.	Psoriasis (Pustulosis Palmaris et Plantaris) 01/01/2018 - "Inhibition of ITK and RLK attenuated psoriasis-associated signaling pathways, indicating that PRN694 is an effective psoriasis therapeutic." 01/01/2018 - "ITK and RLK Inhibitor PRN694 Improves Skin Disease in Two Mouse Models of Psoriasis." 01/01/2018 - "Additionally, PRN694 effectively reduced the psoriasis-like phenotype severity and reduced epidermal proliferation and thickness in both the Rac1V12 and imiquimod mouse models of psoriasis. "
4.	Colitis 11/15/2015 - "Using a T cell adoptive transfer model of colitis, we find that in vivo administration of PRN694 markedly reduces disease progression, T cell infiltration into the intestinal lamina propria, and IFN-γ production by colitogenic CD4(+) T cells. "

Related Drugs and Biologics

1.	Imiquimod (Aldara)