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3- methyl- N- (3- ((3- (trifluoromethyl)phenyl)carbamoyl)phenyl)isoxazole- 5- carboxamide

a LIMK2 inhibitor; structure in first source

Also Known As:

T56-LIMKi

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Demyanenko, Svetlana V: 1 article (01/2021)
2.	Uzdensky, Anatoly: 1 article (01/2021)
3.	Carmeli, Shmuel: 1 article (01/2014)
4.	Elad-Tzfadia, Galit: 1 article (01/2014)
5.	Haklai, Roni: 1 article (01/2014)
6.	Kloog, Yoel: 1 article (01/2014)
7.	Rak, Roni: 1 article (01/2014)
8.	Wolfson, Haim J: 1 article (01/2014)

Related Diseases

1.	Stroke (Strokes) 01/01/2021 - "However, LIMK2 inhibitor T56-LIMKi significantly reduced infarct volume 7 and 14 days after photothrombotic stroke. " 01/01/2021 - "LIM kinase inhibitor T56-LIMKi protects mouse brain from photothrombotic stroke."
2.	Pancreatic Neoplasms (Pancreatic Cancer) 01/01/2014 - "Because the most promising in-vitro effect of T56-LIMKi was observed in the pancreatic cancer cell line Panc-1, we tested the inhibitor on a nude mouse Panc-1 xenograft model. " 01/01/2014 - "We found that T56-LIMKi decreases phosphorylated cofilin (p-cofilin) levels and thus inhibits growth of several cancerous cell lines, including those of pancreatic cancer, glioma and schwannoma. "
3.	Neurilemmoma (Schwannoma) 01/01/2014 - "We found that T56-LIMKi decreases phosphorylated cofilin (p-cofilin) levels and thus inhibits growth of several cancerous cell lines, including those of pancreatic cancer, glioma and schwannoma. "
4.	Neoplasms (Cancer) 01/01/2014 - "T56-LIMKi reduced tumor size and p-cofilin levels in the Panc-1 tumors, leading us to propose T56-LIMKi as a candidate drug for cancer therapy. "
5.	Infarction (Infarctions) 01/01/2021 - "However, LIMK2 inhibitor T56-LIMKi significantly reduced infarct volume 7 and 14 days after photothrombotic stroke. "

Related Drugs and Biologics

1.	Lim Kinases
2.	Actin Depolymerizing Factors (Cofilins)

Related Therapies and Procedures

1.	Therapeutics