N- (1- (7- fluoro- 2- (pyridin- 2- yl)quinolin- 3- yl)ethyl)- 9H- purin- 6- amine

a PI3Kdelta inhibitor; structure in first source

Also Known As:

ACP-319; ACP319; AMG-319; AMG319

Networked: 8 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Purines: 651
      - Purine Nucleosides: 360
        Adenosine: 12431
        N-(1-(7-fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine: 8
    - Quinolines: 146
      - N-(1-(7-fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine: 8
Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleosides: 6847
  - Purine Nucleosides: 360
    - Adenosine: 12431
      - N-(1-(7-fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine: 8
  - Ribonucleosides: 49
    - Adenosine: 12431
      - N-(1-(7-fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine: 8

Experts

1.	Chang, Ping: 2 articles (06/2021 - 01/2021)
2.	Li, Jiahui: 2 articles (06/2021 - 01/2021)
3.	Tang, Haixiong: 2 articles (06/2021 - 01/2021)
4.	Yao, Lihong: 2 articles (06/2021 - 01/2021)
5.	Acton, Gary: 1 article (01/2022)
6.	Ay, Ferhat: 1 article (01/2022)
7.	Barr, Paul M: 1 article (01/2022)
8.	Brennan, Peter A: 1 article (01/2022)
9.	Calvo, Roser: 1 article (01/2022)
10.	Chou, Ting-Fang: 1 article (01/2022)

Related Diseases

1.	Non-Hodgkin Lymphoma (Lymphosarcoma) 01/01/2022 - "Phase 1/2 study of acalabrutinib and the PI3K delta inhibitor ACP-319 in relapsed/refractory B-cell Non-Hodgkin lymphoma."
2.	Head and Neck Neoplasms (Head and Neck Cancer) 01/01/2022 - "Here we assessed the effects of the PI3Kδi AMG319 in human patients with head and neck cancer in a neoadjuvant, double-blind, placebo-controlled randomized phase II trial (EudraCT no. 2014-004388-20). "
3.	Inflammation (Inflammations) 01/08/2015 - "Discovery and in vivo evaluation of (S)-N-(1-(7-fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine (AMG319) and related PI3Kδ inhibitors for inflammation and autoimmune disease." 01/08/2015 - "This medicinal chemistry effort led to the identification of 1 (AMG319), a compound with an IC50 of 16 nM in a human whole blood assay (HWB), excellent selectivity over a large panel of protein kinases, and a high level of in vivo efficacy as measured by two rodent disease models of inflammation. " 06/01/2021 - "Treatment with either IC87114 or AMG319 not only attenuated LPS-induced edema, lung injury and neutrophilc inflammation, reduced total protein concentration and IL-6, TNF-α secretion in BALF, but also restored epithelial E-cadherin and claudin-2 expression. "
4.	Lung Injury 06/01/2021 - "Treatment with either IC87114 or AMG319 not only attenuated LPS-induced edema, lung injury and neutrophilc inflammation, reduced total protein concentration and IL-6, TNF-α secretion in BALF, but also restored epithelial E-cadherin and claudin-2 expression. "
5.	Rodent Diseases 01/08/2015 - "This medicinal chemistry effort led to the identification of 1 (AMG319), a compound with an IC50 of 16 nM in a human whole blood assay (HWB), excellent selectivity over a large panel of protein kinases, and a high level of in vivo efficacy as measured by two rodent disease models of inflammation. "

Related Drugs and Biologics

1.	acalabrutinib
2.	Interleukin-6 (Interleukin 6)
3.	IC 87114
4.	Claudin-2
5.	Interleukin-18 (Interleukin 18)
6.	Interleukin-10 (Interleukin 10)
7.	Interleukin-5 (Interleukin 5)
8.	Interleukin-4 (Interleukin 4)
9.	Cadherins (E-Cadherin)
10.	Proteins (Proteins, Gene)