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3- (4- (morpholin- 4- yl)- 7H- pyrrolo(2,3- d)pyrimidin- 5- yl)benzonitrile

inhibits LRRK2 kinase; structure in first source

Also Known As:

PF-06447475

Networked: 5 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Pyrroles: 369
      - 3-(4-(morpholin-4-yl)-7H-pyrrolo(2,3-d)pyrimidin-5-yl)benzonitrile: 5
  - Pyrimidines: 510
    - 3-(4-(morpholin-4-yl)-7H-pyrrolo(2,3-d)pyrimidin-5-yl)benzonitrile: 5

Experts

1.	Chen, Gang: 1 article (01/2021)
2.	Dang, Baoqi: 1 article (01/2021)
3.	Gong, Yating: 1 article (01/2021)
4.	Li, Jie: 1 article (01/2021)
5.	Shen, Jinchao: 1 article (01/2021)
6.	Tang, Jiafeng: 1 article (01/2021)
7.	Wu, Muyao: 1 article (01/2021)
8.	Xu, Li: 1 article (01/2021)
9.	Jimenez-Del-Rio, Marlene: 1 article (10/2016)
10.	Mendivil-Perez, Miguel: 1 article (10/2016)

Related Diseases

1.	Neuroinflammatory Diseases 01/01/2021 - "The results showed that after SBI, LRRK2 and phosphorylated Rab10 (p-Rab10) expression in neuronal cells were upregulated, and administration of PF-06447475 significantly reduced neuronal apoptosis, neuroinflammation, and brain water content 12 h after SBI and improved neurological deficit 72 h after SBI, which is related to the decreased expression of LRRK2 and p-Rab10, and the lessening of lysosomal overload stress. " 07/06/2023 - "Specifically, we reported that LRRK2 kinase inhibition with MLi2 and PF-06447475 (PF) molecules attenuated neuroinflammation, gliosis and cytotoxicity in mice with intracerebral injection of Aβ1-42 fibrils or α-syn preformed fibrils (pffs). "
2.	Parkinson Disease (Parkinson's Disease) 10/01/2016 - "Neuroprotective Effect of the LRRK2 Kinase Inhibitor PF-06447475 in Human Nerve-Like Differentiated Cells Exposed to Oxidative Stress Stimuli: Implications for Parkinson's Disease."
3.	Gliosis 07/06/2023 - "Specifically, we reported that LRRK2 kinase inhibition with MLi2 and PF-06447475 (PF) molecules attenuated neuroinflammation, gliosis and cytotoxicity in mice with intracerebral injection of Aβ1-42 fibrils or α-syn preformed fibrils (pffs). "
4.	Chronic Disease (Chronic Diseases) 10/30/2023 - "Importantly, the inhibitor of the LRRK2 kinase PF-06447475 (PF-475) almost completely blunted ROT-induced apoptosis and reduced ROT-induced accumulation of lysosomes in both acute and chronic conditions in DALNs. "
5.	Traumatic Brain Injuries (Traumatic Brain Injury) 01/01/2023 - "Moderate traumatic brain injury was induced by controlled cortical impact (CCI) and mice were treated with PF-06447475 at doses of 1, 2.5 and 5 mg/kg once daily for 14 days. "

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