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PF-2771

inhibits CENP-E protein; structure in first source

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Earnshaw, William C: 1 article (03/2016)
2.	Goncharov, Nikolay V: 1 article (03/2016)
3.	Kim, Jung-Hyun: 1 article (03/2016)
4.	Kouprina, Natalay: 1 article (03/2016)
5.	Kumeiko, Vadim: 1 article (03/2016)
6.	Larionov, Vladimir: 1 article (03/2016)
7.	Lee, Hee-Sheung: 1 article (03/2016)
8.	Lee, Nicholas C O: 1 article (03/2016)
9.	Masumoto, Hiroshi: 1 article (03/2016)
10.	Blasina, Alessandra: 1 article (08/2014)

Related Diseases

1.	Chromosomal Instability (Chromosome Stability) 08/01/2014 - "Across a diverse panel of breast cell lines, CENP-E inhibition by PF-2771 selectively inhibits proliferation of basal breast cancer cell lines relative to premalignant ones and its response correlates with the degree of chromosomal instability. " 03/22/2016 - "We verified the accuracy of this "gain of signal" assay by measuring the level of CIN induced by known antimitotic drugs and added to the list of previously ranked CIN inducing compounds, two newly characterized inhibitors of the centromere-associated protein CENP-E, PF-2771 and GSK923295 that exhibit the highest effect on chromosome instability measured to date. "
2.	Neoplasms (Cancer) 08/01/2014 - "Pharmacokinetic-pharmacodynamic efficacy analysis in a basal-a xenograft tumor model shows that PF-2771 exposure is well correlated with increased phospho-HH3-Ser10 levels and tumor growth regression. " 08/01/2014 - "Complete tumor regression is observed in a patient-derived, basal-a breast cancer xenograft tumor model treated with PF-2771. " 08/01/2014 - "Tumor regression is also observed with PF-2771 in a taxane-resistant basal-a model. " 08/01/2014 - "Mechanistic evaluation of PF-2771 in basal-a tumor cells links CENP-E-dependent molecular events (e.g., phosphorylation of histone H3 Ser-10; phospho-HH3-Ser10) to functional outcomes (e.g., chromosomal congression defects). "
3.	Breast Neoplasms (Breast Cancer) 08/01/2014 - "Complete tumor regression is observed in a patient-derived, basal-a breast cancer xenograft tumor model treated with PF-2771. " 08/01/2014 - "Across a diverse panel of breast cell lines, CENP-E inhibition by PF-2771 selectively inhibits proliferation of basal breast cancer cell lines relative to premalignant ones and its response correlates with the degree of chromosomal instability. "

Related Drugs and Biologics

1.	Antimitotic Agents
2.	Proteins (Proteins, Gene)
3.	Histones (Histone)
4.	GSK923295
5.	taxane