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RO5461111

a cathepsin S antagonist

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - Cyclic Amino Acids: 3
    - Imino Acids: 11
      - Proline: 3391
        RO5461111: 1

Experts

1.	Anders, Hans-Joachim: 1 article (02/2015)
2.	Darisipudi, Murthy Narayana: 1 article (02/2015)
3.	Gruner, Sabine: 1 article (02/2015)
4.	Haap, Wolfgang: 1 article (02/2015)
5.	Hartmann, Guido: 1 article (02/2015)
6.	Kulkarni, Onkar P: 1 article (02/2015)
7.	Lichtnekert, Julia: 1 article (02/2015)
8.	Mulay, Shrikant R: 1 article (02/2015)
9.	Rupanagudi, Khader Valli: 1 article (02/2015)
10.	Schott, Brigitte: 1 article (02/2015)

Related Diseases

1.

Lupus Nephritis

02/01/2015 - "When given to MRL-Fas(lpr) mice with SLE and lupus nephritis, RO5461111 significantly reduced the activation of spleen dendritic cells and the subsequent expansion and activation of CD4 T cells and CD4/CD8 double-negative T cells. "
02/01/2015 - "These afferent immune pathways can be specifically reversed with the cathepsin S antagonist RO5461111, which prevents lupus nephritis progression even when given after disease onset. "

Related Drugs and Biologics

1.	cathepsin S