isosclerone

antineoplastic from marine-derived fungus Aspergillus; structure in first source

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

1.	Breast Neoplasms (Breast Cancer) 08/15/2014 - "In the present study, we investigated the apoptotic effects of isosclerone from marine-derived fungi on human breast cancer MCF-7 cells. "
2.	Neoplasms (Cancer) 08/15/2014 - "Treatment with isosclerone exhibited a characteristic feature of apoptosis including significant cytotoxicity and DNA fragmentation in cancer cells. " 08/15/2014 - "Western blot and RT-PCR analysis have indicated that isosclerone induce cancer cells apoptosis through down-regulated Bcl-2 family and up-regulated caspases, and activating the NF-κ-B signaling pathway. "

1.	Caspases