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2- (1- (4- (2- cyanophenyl)1- benzyl- 1H- indol- 3- yl)- 5- (4- methoxy- phenyl)- 1- oxa- 3- azaspiro(5,5)undecane

antineoplastic; structure in first source

Also Known As:

CIMO compound

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Spiro Compounds: 2
      - 2-(1-(4-(2-cyanophenyl)1-benzyl-1H-indol-3-yl)-5-(4-methoxy-phenyl)-1-oxa-3-azaspiro(5,5)undecane: 1
Polycyclic Compounds: 6
- Spiro Compounds: 2
  - 2-(1-(4-(2-cyanophenyl)1-benzyl-1H-indol-3-yl)-5-(4-methoxy-phenyl)-1-oxa-3-azaspiro(5,5)undecane: 1

Experts

1.	Basappa,: 1 article (12/2014)
2.	Bender, Andreas: 1 article (12/2014)
3.	Bharathkumar, Hanumantharayappa: 1 article (12/2014)
4.	Bulusu, Krishna C: 1 article (12/2014)
5.	Dai, Xiaoyun: 1 article (12/2014)
6.	Deivasigamani, Amudha: 1 article (12/2014)
7.	Fuchs, Julian E: 1 article (12/2014)
8.	Hui, Kam M: 1 article (12/2014)
9.	Kumar, Alan Prem: 1 article (12/2014)
10.	Li, Feng: 1 article (12/2014)

Related Diseases

1.

Hepatocellular Carcinoma (Hepatoma)

12/05/2014 - "In this work, we present the synthesis of N-substituted azaspirane derivatives and their biological evaluation against hepatocellular carcinoma (HCC) cells (IC50 = 7.3 μm), thereby identifying 2-(1-(4-(2-cyanophenyl)1-benzyl-1H-indol-3-yl)-5-(4-methoxy-phenyl)-1-oxa-3-azaspiro(5,5) undecane (CIMO) as a potent inhibitor of the JAK-STAT pathway with selectivity over normal LO2 cells (IC50 > 100 μm). "

Related Drugs and Biologics

1.	azaspirane