teixobactin

05/26/2020 - "To conclude, this is the first study to provide novel metabolomics mechanistic information, which lends support to the development of teixobactin as an antibacterial drug for the treatment of multidrug-resistant Gram-positive infections.IMPORTANCE Antimicrobial resistance is one of the greatest threats to the global health system. "
06/26/2018 - "The antimicrobial effectiveness of a [Tfn10 ,Nle11 ]teixobactin (32 μg mL-1 )-colistin (2 μg mL-1 ; 0.5×MIC) combination against P. aeruginosa PAO1 reveals, for the first time, an alternative therapeutic option in the treatment of Gram-negative infections."
10/01/2015 - "In experimental infections of MRSA and Streptococcus pneumoniae in mice, teixobactin was effective at reducing the bacterial load. "
09/22/2020 - "Overall, these results show that teixobactin was protective against inhalation anthrax infection in the rabbit model, and they indicate the potential of teixobactin as a therapeutic for the disease."
09/22/2020 - "Rabbits treated with teixobactin showed 100% survival following infection, and the bacteremia was completely resolved by 24-48 h post-treatment. "

09/22/2020 - "Teixobactin Provides Protection against Inhalation Anthrax in the Rabbit Model."
09/22/2020 - "Overall, these results show that teixobactin was protective against inhalation anthrax infection in the rabbit model, and they indicate the potential of teixobactin as a therapeutic for the disease."
09/22/2020 - "In this blinded study, we assessed the protective efficacy of teixobactin, a recently discovered antibiotic, against inhalation anthrax infection in the adult rabbit model. "

01/01/2018 - "Collectively, our results have established the high therapeutic potential of a teixobactin analogue in attenuating bacterial infections and associated severities in vivo."
12/05/2023 - "Our results suggest that the use of hydrophobic, non-proteogenic amino acids at position 10 in combination with arginine at positions 3, 4 and 9 holds the key to synthesising a new generation of highly potent teixobactin analogues to tackle resistant bacterial infections and biofilms."

03/01/2015 - "Teixobactin: a novel antibiotic in treatment of gram positive bacterial infections."

09/22/2020 - "Rabbits treated with teixobactin showed 100% survival following infection, and the bacteremia was completely resolved by 24-48 h post-treatment. "