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N- (5- bromopyridin- 2- yl)- 2- ((6- (2- chloroacetamido)benzo(d)thiazol- 2- yl)thio)acetamide

has antineoplastic activity; structure in first source

Also Known As:

YLT205

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amides: 2428
  - Acetamides: 21
    - N-(5-bromopyridin-2-yl)-2-((6-(2-chloroacetamido)benzo(d)thiazol-2-yl)thio)acetamide: 1
- Carboxylic Acids: 973
  - Acyclic Acids
    - Acetates: 4994
      - Acetamides: 21
        N-(5-bromopyridin-2-yl)-2-((6-(2-chloroacetamido)benzo(d)thiazol-2-yl)thio)acetamide: 1
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Thiazoles: 392
      - Benzothiazoles: 40
        N-(5-bromopyridin-2-yl)-2-((6-(2-chloroacetamido)benzo(d)thiazol-2-yl)thio)acetamide: 1
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzothiazoles: 40
      - N-(5-bromopyridin-2-yl)-2-((6-(2-chloroacetamido)benzo(d)thiazol-2-yl)thio)acetamide: 1

Experts

1.	Han, Yuanping: 1 article (01/2014)
2.	Liu, Li: 1 article (01/2014)
3.	Luo, Yong: 1 article (01/2014)
4.	Shi, Xuanhong: 1 article (01/2014)
5.	Song, Xuejiao: 1 article (01/2014)
6.	Wang, Ningyu: 1 article (01/2014)
7.	Xia, Yong: 1 article (01/2014)
8.	Ye, Tinghong: 1 article (01/2014)
9.	Yu, Luoting: 1 article (01/2014)
10.	Zeng, Jun: 1 article (01/2014)

Related Diseases

1.	Colorectal Neoplasms (Colorectal Cancer) 01/01/2014 - "These studies suggested that YLT205 might be a potential drug candidate for human colorectal cancer therapy."
2.	Neoplasms (Cancer) 01/01/2014 - "Immunohistochemistry analyses revealed YLT205 also induced apoptosis and inhibited tumor cell proliferation in vivo. " 01/01/2014 - "Furthermore, in HCT116 and SW620 tumor-bearing nude mice models, YLT205 dose-dependently inhibited tumor growth without obvious adverse effects. " 01/01/2014 - "A novel small-molecule YLT205 induces apoptosis in human colorectal cells via mitochondrial apoptosis pathway in vitro and inhibits tumor growth in vivo." 01/01/2014 - "The activities of N-(5-bromopyridin-2-yl)-2-((6-(2-chloroacetamido)benzo[d]thiazol-2-yl)thio)acetamide (YLT205), which is a novel small molecule compound synthesized by us, were investigated using MTT assay, flow cytometry, western blotting and mice tumor xenograft models. "

Related Drugs and Biologics

1.	acetamide

Related Therapies and Procedures

1.	Therapeutics