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4- (1- acetyl- 4- ((4- chlorophenyl)amino)- 2- methyl- 1,2,3,4- tetrahydroquinolin- 6- yl)benzoic acid

a BET bromodomain inhibitor; structure in first source

Also Known As:

GSK1324726A; I-BET726

Networked: 4 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinolines: 146
      - Aminoquinolines: 29
        4-(1-acetyl-4-((4-chlorophenyl)amino)-2-methyl-1,2,3,4-tetrahydroquinolin-6-yl)benzoic acid: 4
Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Benzoates: 426
        4-(1-acetyl-4-((4-chlorophenyl)amino)-2-methyl-1,2,3,4-tetrahydroquinolin-6-yl)benzoic acid: 4
- Carboxylic Acids: 973
  - Carbocyclic Acids
    - Benzoates: 426
      - 4-(1-acetyl-4-((4-chlorophenyl)amino)-2-methyl-1,2,3,4-tetrahydroquinolin-6-yl)benzoic acid: 4

Experts

1.	Barbash, Olena: 2 articles (01/2020 - 01/2013)
2.	Wyce, Anastasia: 2 articles (01/2020 - 01/2013)
3.	Basu, Mousumi: 1 article (01/2021)
4.	Lazarski, Christopher: 1 article (01/2021)
5.	Nelson, Marie: 1 article (01/2021)
6.	Sandler, Anthony David: 1 article (01/2021)
7.	Srinivasan, Priya: 1 article (01/2021)
8.	Wu, Xiaofang: 1 article (01/2021)
9.	Zhang, Peng: 1 article (01/2021)
10.	Zheng, Pan: 1 article (01/2021)

Related Diseases

1.	Neuroblastoma 01/01/2013 - "We treated a panel of neuroblastoma cell lines with a novel small molecule inhibitor of BET proteins, GSK1324726A (I-BET726), and observed potent growth inhibition and cytotoxicity in most cell lines irrespective of MYCN copy number or expression level. " 01/01/2013 - "Oral administration of I-BET726 to mouse xenograft models of human neuroblastoma results in tumor growth inhibition and down-regulation MYCN and BCL2 expression, suggesting a potential role for these genes in tumor growth. " 01/01/2020 - "Therefore, we examined the antitumor efficacy of combined BET/MEK inhibition utilizing I-BET726 or I-BET762 and trametinib in high-risk neuroblastoma. "
2.	Neoplasms (Cancer) 01/01/2021 - "Targeting Myc in cancer cells with I-BET726 and JQ1 results in cell cycle arrest and induces cell immunogenicity. " 01/01/2013 - "Oral administration of I-BET726 to mouse xenograft models of human neuroblastoma results in tumor growth inhibition and down-regulation MYCN and BCL2 expression, suggesting a potential role for these genes in tumor growth. "
3.	Squamous Cell Carcinoma (Epidermoid Carcinoma) 01/01/2020 - "I-BET726 suppresses human skin squamous cell carcinoma cell growth in vitro and in vivo."

Related Drugs and Biologics

1.	Mitogen-Activated Protein Kinase Kinases (MEKs)
2.	trametinib
3.	molibresib
4.	Proteins (Proteins, Gene)

Related Therapies and Procedures

1.	Oral Administration