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APY0201

a small molecular IL-12/23 inhibitor with pyrazolo[1,5-a]pyrimidine core; structure in first source

Networked: 3 relevant articles (1 outcomes, 1 trials/studies)

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Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Pyrazoles: 61
      - APY0201: 3
  - Pyrimidines: 510
    - APY0201: 3

Experts

1.	Ahmann, Gregory J: 1 article (01/2020)
2.	Armenta, Ilsel D Lopez: 1 article (01/2020)
3.	Bergsagel, P Leif: 1 article (01/2020)
4.	Braggio, Esteban: 1 article (01/2020)
5.	Bruins, Laura Ann: 1 article (01/2020)
6.	Chesi, Marta: 1 article (01/2020)
7.	Kruse, Jonas: 1 article (01/2020)
8.	Meermeier, Erin W: 1 article (01/2020)
9.	Meurice, Nathalie: 1 article (01/2020)
10.	Petit, Joachim L: 1 article (01/2020)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2022 - "Importantly, APY0201 was also effective in inducing repression of autophagy and cell cycle arrest in the mouse tumor xenograft. " 01/01/2022 - "In this study, we investigate the effect of APY0201, an inhibitor of PIKfyve, on GC tumor growth and its mechanism of action. " 01/01/2022 - "It was found that APY0201 inhibited GC cell proliferation in in vitro GC cell model, organoid model, and in vivo xenograft tumor model. " 01/01/2022 - "APY0201 Represses Tumor Growth through Inhibiting Autophagy in Gastric Cancer Cells."
2.	Trisomy (Trisomies) 01/01/2020 - "The activity of APY0201 was confirmed in all 25 cell lines tested and in 40% of 100 ex vivo patient-derived primary samples, with increased activity in primary samples harboring trisomies and lacking t(11;14). "
3.	Stomach Neoplasms (Stomach Cancer) 01/01/2022 - "APY0201 Represses Tumor Growth through Inhibiting Autophagy in Gastric Cancer Cells."
4.	Multiple Myeloma 01/01/2020 - "The cellular cytotoxicity of APY0201, a PIKfyve inhibitor, against multiple myeloma was initially identified in an unbiased in vitro chemical library screen. " 01/01/2020 - "The broad anti-multiple myeloma activity of PIKfyve inhibitors was further demonstrated in confirmatory screens and showed the superior potency of APY0201 when compared to the PIKfyve inhibitors YM201636 and apilimod, with a mid-point half maximal effective concentration (EC50) at nanomolar concentrations in, respectively, 65%, 40%, and 5% of the tested cell lines. "
5.	Inflammation (Inflammations) 06/01/2014 - "We describe the discovery of APY0201, a unique small molecular IL-12/23 production inhibitor, from activated macrophages and monocytes, and demonstrate ameliorated inflammation in an experimental model of colitis. "

Related Drugs and Biologics

1.	Interleukin-12 (IL 12)
2.	6- amino- N- (3- (4- (4- morpholinyl)pyrido(3',2'- 4,5)furo(3,2- d)pyrimidin- 2- yl)phenyl)- 3- pyridinecarboxamide
3.	apilimod