1- ((2- ((2- chloropyridin- 4yl)amino)- 4'- (cyclopropylmethyl)- (4,5'- bipyrimidin)- 2'- yl)amino)- 2- methylpropan- 2- ol

01/01/2023 - "Collectively, VPS34-IN1 has an antitumor effect in breast cancer, and it may result from activating PERK/ATF4/CHOP pathway of ER stress to induce cell apoptosis. "
01/01/2023 - "Flow cytometry and western blot analyses showed that VPS34-IN1 treatment induced breast cancer cell apopotosis. "
01/01/2023 - "These findings broaden our understanding of the anti-breast cancer effects and mechanisms of VPS34-IN1 and provide new ideas and reference directions for the treatment of ER+ breast cancer."
01/01/2023 - "In current study, we focused on the anticancer effect and potential mechanism of VPS34-IN1 in estrogen receptor positive (ER+ ) breast cancer. "
08/12/2022 - "This study identifies IC87114 and Vps34-IN1 as potential therapeutic approaches in breast cancer."

08/12/2022 - "Therefore, we tested the PI3K p110δ-selective inhibitor, IC87114, and Vps34-selective inhibitor, Vps34-IN1, on the breast cancer cell lines MCF-7 and MDA-MB-231, representing hormone-responsive and triple-negative breast cancer cells, respectively. "

10/22/2020 - "Antileukemic activity of the VPS34-IN1 inhibitor in acute myeloid leukemia."

11/02/2017 - "Similar to Vps34-deficient platelets, ex vivo treatment of wild-type mouse or human platelets with the Vps34-specific inhibitors, SAR405 and VPS34-IN1, induced abnormal secretion and affected thrombus growth at arterial shear rate, indicating a role for Vps34 kinase activity in platelet activation, independent from its role in MKs. "

01/01/2018 - "No significant changes were observed in both infection rate or parasite load in macrophages treated with the autophagic inhibitors wortmannin, chloroquine or VPS34-IN1, as well as with the autophagic inducers rapamycin or physiological starvation, in comparison to untreated control cells. "