arhalofenate

01/01/2016 - "A Randomized, Double-Blind, Active- and Placebo-Controlled Efficacy and Safety Study of Arhalofenate for Reducing Flare in Patients With Gout."
01/01/2017 - "Arhalofenate (ARH), in development for gout, has uricosuric and anti-flare activities. "
01/01/2016 - "Crystal arthritis: Arhalofenate safely prevents gout flare."
01/01/2018 - "Arhalofenate also acts by blocking URAT-1; however, it also blocks the NALP-3 inflammasome providing gout-specific anti-inflammatory effect. "
12/01/2017 - "Arhalofenate, an emerging uricosuric anti-inflammatory drug, prevents gout flares while reducing serum urate. "

11/01/2020 - "The mechanism of Arhalofenate in alleviating hyperuricemia-Activating PPARγ thereby reducing caspase-1 activity."
01/01/2017 - "The Pharmacodynamics, Pharmacokinetics, and Safety of Arhalofenate in Combination with Febuxostat When Treating Hyperuricemia Associated with Gout."
11/29/2021 - "Women were proportionally underrepresented compared with their share of the population with asymptomatic hyperuricemia, overall (participation-to-prevalence ratio (PPR) = 0.34), in trials testing xanthine oxiase inhibitors (PPR = 0.38) and uricosurics (PPR = 0.29), and in trials with febuxostat, allopurinol, pegloticase, halofenate/arhalofenate, verinurad, lesinurad and dotinurad. "

01/01/2018 - "Phase II studies revealed decreased acute arthritis flares in arhalofenate-treated gout compared with allopurinol alone. "

01/01/2008 - "MBX-102 acid/JNJ39659100 is a novel PPAR-gamma agonist in development for the treatment of type 2 diabetes. "

07/01/2009 - "In diabetic rodent models, MBX-102 has insulin-sensitizing and glucose-lowering properties comparable to TZDs without dose-dependent increases in body weight. "