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1- (4- ((1H- pyrazolo(3,4- d)pyrimidin- 4- yl)oxy)- 2- fluorophenyl)- 3- (4- chloro- 3- (trifluoromethyl)phenyl)urea

inhibits VEGFR-1, VEGFR-2, VEGFR-3, FGFR2, and Src kinase; has antineoplastic activity; structure in first source

Also Known As:

SKLB-329

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amides: 2428
  - Urea: 15015
    - Phenylurea Compounds: 1
      - 1-(4-((1H-pyrazolo(3,4-d)pyrimidin-4-yl)oxy)-2-fluorophenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea: 1
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Phenylurea Compounds: 1
        1-(4-((1H-pyrazolo(3,4-d)pyrimidin-4-yl)oxy)-2-fluorophenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea: 1
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Pyrazoles: 61
      - 1-(4-((1H-pyrazolo(3,4-d)pyrimidin-4-yl)oxy)-2-fluorophenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea: 1

Experts

1.	Chen, Li-Juan: 1 article (12/2014)
2.	Chen, Yu-Zong: 1 article (12/2014)
3.	Cheng, Chuan: 1 article (12/2014)
4.	Fu, Xiao-Yu: 1 article (12/2014)
5.	Li, Lin-Li: 1 article (12/2014)
6.	Tang, Yun: 1 article (12/2014)
7.	Wei, Yu-Quan: 1 article (12/2014)
8.	Xiang, Rong: 1 article (12/2014)
9.	Yang, Jiao: 1 article (12/2014)
10.	Yang, Ling-Ling: 1 article (12/2014)

Related Diseases

1.	Neoplasms (Cancer) 12/15/2014 - "In vivo, oral administration of SKLB-329 considerably suppressed the tumor growth in HCC xenograft models (HepG2 and SMMC7721) in a dose-dependent manner. "
2.	Hepatocellular Carcinoma (Hepatoma) 12/15/2014 - "A preclinical evaluation of a novel multikinase inhibitor, SKLB-329, as a therapeutic agent against hepatocellular carcinoma."

Related Therapies and Procedures

1.	Oral Administration