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setrobuvir

an antiviral agent with polymerase NS5B inhibitory activity; structure in first source

Also Known As:

ANA598

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thiazides: 1584
    - Benzothiadiazines: 3
      - setrobuvir: 2
  - Sulfones: 534
    - Sulfonamides: 2809
      - Benzothiadiazines: 3
        setrobuvir: 2
Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinolines: 146
      - Quinolones: 2938
        setrobuvir: 2
    - Benzothiadiazines: 3
      - setrobuvir: 2

Experts

1.	ANNAPURNA study investigators: 1 article (04/2016)
2.	Brunda, Michael: 1 article (04/2016)
3.	Chu, Tom: 1 article (04/2016)
4.	Elston, Robert: 1 article (04/2016)
5.	Gane, Edward J: 1 article (04/2016)
6.	George, Jacob: 1 article (04/2016)
7.	Glavini, Katerina: 1 article (04/2016)
8.	Hammond, Janet M: 1 article (04/2016)
9.	Jensen, Donald M: 1 article (04/2016)
10.	Le Pogam, Sophie: 1 article (04/2016)

Related Diseases

1.	Chronic Hepatitis C 04/01/2016 - "Interferon-free regimens containing setrobuvir for patients with genotype 1 chronic hepatitis C: a randomized, multicenter study."
2.	Hepatitis C 06/15/2014 - "The direct-acting antivirals (DAAs) currently in development for treatment of hepatitis C fall into four categories: (i) NS3/4A protease inhibitors: ABT-450/r, faldaprevir, asunaprevir, GS-9256, vedroprevir (GS-9451), danoprevir, MK-5172, vaniprevir, sovaprevir, ACH-2684, narlaprevir and simeprevir, in addition to those that are already developed [telaprevir (Incivek®) and boceprevir (Victrelis®)], (ii) NS5A protein inhibitors: ABT-267, daclatasvir, ledipasvir, ACH-2928, ACH-3102, PPI-668, AZD-7295, MK-8742, and GSK 2336805; (iii) NS5B (nucleoside-type) polymerase inhibitors: sofosbuvir (now approved by the FDA since 6 December 2013), GS-0938, mericitabine, VX-135, ALS 2158 and TMC 649128; (iv) NS5B (non-nucleoside-type) polymerase inhibitors: VX-222, ABT-072, ABT-333, deleobuvir, tegobuvir, setrobuvir, VCH-916, VCH-759, BMS-791325 and TMC-647055. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Nucleosides
3.	Interferons
4.	Antiviral Agents (Antivirals)
5.	HCV NS3-4A Protease Inhibitors
6.	Simeprevir
7.	Sofosbuvir
8.	dasabuvir
9.	8- cyclohexyl- N- ((dimethylamino)sulfonyl)- 1,1a,2,12b- tetrahydro- 11- methoxy- 1a- ((3- methyl- 3,8- diazabicyclo(3.2.1)oct- 8- yl)carbonyl)cycloprop(d)indolo(2,1- a)(2)benzazepine- 5- carboxamide
10.	ledipasvir