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2- amino- N,N- dimethyl- 5- (3- (2- methylpyridin- 4- yl)- 1H- pyrrolo(2,3- b)pyridin- 5- yl)pyridine- 3- sulfonamide)

inhibits the p110 catalytic subunit of PI3Kalpha and has antineoplastic activity; structure in first source

Also Known As:

HS-527

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - Aminopyridines: 77
      - 2-amino-N,N-dimethyl-5-(3-(2-methylpyridin-4-yl)-1H-pyrrolo(2,3-b)pyridin-5-yl)pyridine-3-sulfonamide): 1

Experts

1.	Hong, Soon-Sun: 1 article (10/2014)
2.	Hong, Sungwoo: 1 article (10/2014)
3.	Jung, Kyung Hee: 1 article (10/2014)
4.	Kim, Soo Jung: 1 article (10/2014)
5.	Ryu, Ye-Lim: 1 article (10/2014)
6.	Shin, Sanghye: 1 article (10/2014)
7.	Son, Mi Kwon: 1 article (10/2014)
8.	Yan, Hong Hua: 1 article (10/2014)

Related Diseases

1.	Pancreatic Neoplasms (Pancreatic Cancer) 10/10/2014 - "In this study, we found that HS-527 showed anti-cancer activity through an inhibition of the PI3K/Akt pathway in pancreatic cancer cells, suggesting that HS-527 could be used as a promising therapeutic agent for pancreatic cancer. " 10/10/2014 - "In this study, we synthesized HS-527, a new PI3-kinase inhibitor, and investigated not only its anticancer activity, but also its mechanism of action in pancreatic cancer cells. " 10/10/2014 - "And HS-527 inhibited the cell growth and proliferation of the pancreatic cancer in a time- and dose-dependent manner, with greater activity than gemcitabine. " 10/10/2014 - "Anticancer activity of HS-527, a novel inhibitor targeting PI3-kinase in human pancreatic cancer cells."
2.	Neoplasms (Cancer) 10/10/2014 - "In this study, we found that HS-527 showed anti-cancer activity through an inhibition of the PI3K/Akt pathway in pancreatic cancer cells, suggesting that HS-527 could be used as a promising therapeutic agent for pancreatic cancer. " 10/10/2014 - "When treated with HS-527, the cancer cells appeared apoptotic, increasing the expression of cleaved PARP, cleaved caspase-3, and Bax. "

Related Drugs and Biologics

1.	Phosphatidylinositol 3-Kinases (PI 3 Kinase)
2.	Caspase 3 (Caspase-3)
3.	Gemcitabine