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bis(1,2- dimethyl- 3- hydroxy- 4- pyridinonato)oxidovanadium(IV)

has antidiabetic activity; structure in first source

Also Known As:

VO(dmpp)2

Networked: 3 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Inorganic Chemicals: 9
- Coordination Complexes: 576
  - bis(1,2-dimethyl-3-hydroxy-4-pyridinonato)oxidovanadium(IV): 3
Organic Chemicals: 133
- Coordination Complexes: 576
  - bis(1,2-dimethyl-3-hydroxy-4-pyridinonato)oxidovanadium(IV): 3

Experts

1.	Castro, M Margarida C A: 2 articles (01/2016 - 10/2012)
2.	Domingues, Neuza: 1 article (01/2016)
3.	Pelletier, Julien: 1 article (01/2016)
4.	Östenson, Claes-Göran: 1 article (01/2016)
5.	Castro, M M C A: 1 article (02/2014)
6.	Domingues, N: 1 article (02/2014)
7.	Ostenson, C-G: 1 article (02/2014)
8.	Pelletier, J: 1 article (02/2014)
9.	López-Larrubia, Pilar: 1 article (10/2012)
10.	Metelo, Ana M: 1 article (10/2012)

Related Diseases

1.	Body Weight (Weight, Body) 10/01/2012 - "For 4 weeks fatty Zucker rats were subjected to a daily dose of VO(dmpp)(2) (44 μmol/kg) and their metabolic profile was followed by assessing different biological parameters at established time points: body weight, subcutaneous fat width and hepatic triglyceride content determined by magnetic resonance imaging and spectroscopy, respectively. " 02/01/2014 - "It was shown that VO(dmpp)2 doesn't affect the normal increase of body weight of both W and GK rats, after 8 days of treatment ameliorates glycemia in GK rats (8.4 ± 0.3 vs 10.1 ± 0.2 mM in GK control, P<0.001) but doesn't interfere with glucose levels in W rats and, after 21 days of treatment, improves the glucose intolerant profile of GK rats (13.1 ± 0.5 vs 20.6 ± 0.7 mM/min in GK control, P<0.001), despite no increase of plasma insulin levels during glucose tolerance test. "
2.	Type 2 Diabetes Mellitus (MODY) 01/01/2016 - "We have recently shown that bis(1,2-dimethyl-3-hydroxy-4-pyridinonato)oxidovanadium(IV), VO(dmpp)2, has promising effects when compared to another vanadium compound, bis(maltolato)oxidovanadium(IV), BMOV, and insulin itself, in isolated adipocytes and in vivo in Goto-Kakizaki (GK) rats, an animal model of hereditary type 2 diabetes (T2D).We now have investigated in GK rats whether VO(dmpp)2 also modulates another important defect in T2D, impaired insulin secretion. "

Related Drugs and Biologics

1.	Insulin (Novolin)
2.	Glucose (Dextrose)
3.	bis(1,2- dimethyl- 3- hydroxy- 4- pyridinonato)oxidovanadium(IV)
4.	Vanadium
5.	Triglycerides (Triacylglycerol)