Agkistrodon acutus agkisacucetin protein

has antithrombotic activity

Also Known As:

agkisacucetin protein, Agkistrodon acutus; anfibatide

Networked: 11 relevant articles (3 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Complex Mixtures: 1906
- Venoms: 4328
  - Snake Venoms: 1139
    - Viper Venoms: 122
      - Crotalid Venoms: 67
        Agkistrodon acutus agkisacucetin protein: 11
Biological Factors: 2472
- Biological Toxins: 20
  - Venoms: 4328
    - Snake Venoms: 1139
      - Viper Venoms: 122
        Crotalid Venoms: 67
        Agkistrodon acutus agkisacucetin protein: 11
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Lectins: 6782
    - C-Type Lectins: 976
      - Agkistrodon acutus agkisacucetin protein: 11

Experts

1.	Dai, Xiangrong: 5 articles (10/2021 - 02/2014)
2.	Luo, Sheng-Yong: 4 articles (07/2022 - 08/2015)
3.	Dai, Xiang-Rong: 3 articles (07/2022 - 08/2015)
4.	Li, Rui: 3 articles (07/2022 - 07/2017)
5.	Li, Xiao-Yi: 3 articles (07/2022 - 08/2015)
6.	Gong, Peng: 2 articles (07/2022 - 01/2020)
7.	Jia, Hui-Yu: 2 articles (07/2022 - 01/2020)
8.	Ma, Zheng: 2 articles (07/2022 - 01/2020)
9.	Li, Benjamin: 2 articles (10/2021 - 11/2016)
10.	Zhou, Lanlan: 2 articles (08/2021 - 01/2018)

Related Diseases

1.	Ischemic Stroke 08/01/2015 - "Anfibatide is a promising candidate that could be beneficial for the treatment of ischaemic stroke." 01/01/2018 - "Anfibatide, as a promising anti-thrombo-inflammation agent, could be beneficial for the treatment of ischemic stroke." 07/05/2022 - "Anfibatide alleviates inflammation and apoptosis via inhibiting NF-kappaB/NLRP3 axis in ischemic stroke." 08/01/2015 - "A novel snake venom-derived GPIb antagonist, anfibatide, protects mice from acute experimental ischaemic stroke and reperfusion injury."
2.	Reperfusion Injury 08/01/2015 - "Our data indicate anfibatide is a safe GPIb antagonist that exerts a protective effect on cerebral ischaemia and reperfusion injury. " 01/01/2018 - "This research was conducted to explore the therapeutic efficacy and potential mechanisms of GPIbα inhibitor (anfibatide) in a model of brain ischemia-reperfusion injury in mice. " 01/01/2020 - "Anfibatide Preserves Blood-Brain Barrier Integrity by Inhibiting TLR4/RhoA/ROCK Pathway After Cerebral Ischemia/Reperfusion Injury in Rat." 07/15/2017 - "Anfibatide protects against rat cerebral ischemia/reperfusion injury via TLR4/JNK/caspase-3 pathway." 08/01/2015 - "A novel snake venom-derived GPIb antagonist, anfibatide, protects mice from acute experimental ischaemic stroke and reperfusion injury."
3.	Brain Ischemia (Cerebral Ischemia) 01/01/2018 - "This research was conducted to explore the therapeutic efficacy and potential mechanisms of GPIbα inhibitor (anfibatide) in a model of brain ischemia-reperfusion injury in mice. " 01/01/2020 - "Anfibatide Preserves Blood-Brain Barrier Integrity by Inhibiting TLR4/RhoA/ROCK Pathway After Cerebral Ischemia/Reperfusion Injury in Rat." 08/01/2021 - "Previously, we have observed that the GPIb antagonist anfibatide (ANF) could mitigate blood-brain barrier (BBB) disruption following cerebral ischemia/reperfusion (CI/R) injury. " 07/15/2017 - "Anfibatide protects against rat cerebral ischemia/reperfusion injury via TLR4/JNK/caspase-3 pathway."
4.	Inflammation (Inflammations) 01/01/2018 - "This is the first demonstration of anfibatide's efficacy in protecting the BBB integrity and decreasing neutrophil inflammation response mediated by MAC-1 besides microthrombus formation inhibition in the brain during reperfusion. " 01/01/2018 - "Anfibatide, as a promising anti-thrombo-inflammation agent, could be beneficial for the treatment of ischemic stroke." 07/05/2022 - "Anfibatide alleviates inflammation and apoptosis via inhibiting NF-kappaB/NLRP3 axis in ischemic stroke."
5.	Thrombotic Thrombocytopenic Purpura 11/29/2016 - "Therapeutic efficacy of the platelet glycoprotein Ib antagonist anfibatide in murine models of thrombotic thrombocytopenic purpura."

Related Drugs and Biologics

1.	Platelet Membrane Glycoproteins
2.	Antibodies
3.	Snake Venoms (Snake Venom)
4.	Caspase 3 (Caspase-3)
5.	Shiga Toxin (Shigella Toxin)
6.	P-Selectin
7.	NF-kappa B (NF-kB)
8.	Macrophage-1 Antigen (Macrophage 1 Antigen)
9.	Thrombin
10.	Ristocetin

Related Therapies and Procedures

1.	Intravenous Administration
2.	Lasers (Laser)