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(7- fluoro- 1- (2- methylpropyl)- 2- oxo- 1,2- dihydro- 3H- indol- 3- ylidene)acetic acid

a TRPA1 agonist with analgesic activity; structure in first source

Also Known As:

ASP7663

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - Indoleacetic Acids: 615
        (7-fluoro-1-(2-methylpropyl)-2-oxo-1,2-dihydro-3H-indol-3-ylidene)acetic acid: 1
- Heterocyclic Acids
  - Indoleacetic Acids: 615
    - (7-fluoro-1-(2-methylpropyl)-2-oxo-1,2-dihydro-3H-indol-3-ylidene)acetic acid: 1

Experts

1.	Doihara, Hitoshi: 1 article (01/2014)
2.	Itou, Hiroyuki: 1 article (01/2014)
3.	Kaku, Hidetaka: 1 article (01/2014)
4.	Keto, Yoshihiro: 1 article (01/2014)
5.	Kojima, Ryosuke: 1 article (01/2014)
6.	Nozawa, Katsura: 1 article (01/2014)
7.	Yokoyama, Toshihide: 1 article (01/2014)

Related Diseases

1.	Visceral Pain 01/15/2014 - "Effects of novel TRPA1 receptor agonist ASP7663 in models of drug-induced constipation and visceral pain."
2.	Abdominal Pain (Pain, Abdominal) 01/15/2014 - "Taken together, these results demonstrate that ASP7663 exerts both anti-constipation and anti-abdominal pain actions, the former is likely triggered from the mucosal side of the gut wall via activation of vagus nerves while the latter is assumed to be provoked through systemic blood flow. " 01/15/2014 - "Here, we examined the effects of ASP7663, a novel and selective TRPA1 agonist, in constipation models as well as an abdominal pain model. " 01/15/2014 - "While pretreatment with the TRPA1 antagonist HC-030031 and vagotomy both inhibited the ameliorating effect of oral ASP7663 on the colonic transit, both orally and intravenously administered ASP7663 significantly inhibited colorectal distension (CRD)-induced abdominal pain response in rats. "
3.	Constipation 01/15/2014 - "Taken together, these results demonstrate that ASP7663 exerts both anti-constipation and anti-abdominal pain actions, the former is likely triggered from the mucosal side of the gut wall via activation of vagus nerves while the latter is assumed to be provoked through systemic blood flow. " 01/15/2014 - "Here, we examined the effects of ASP7663, a novel and selective TRPA1 agonist, in constipation models as well as an abdominal pain model. " 01/15/2014 - "Effects of novel TRPA1 receptor agonist ASP7663 in models of drug-induced constipation and visceral pain." 01/15/2014 - "We conclude that ASP7663 can be an effective anti-constipation drug with abdominal analgesic effect. "

Related Drugs and Biologics

1.	Analgesics (Analgesic Drugs)
2.	2- (1,3- dimethyl- 2,6- dioxo- 1,2,3,6- tetrahydro- 7H- purin- 7- yl)- N- (4- isopropylphenyl)acetamide

Related Therapies and Procedures

1.	Vagotomy