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isobutyric acid 2- (2- ((3- (4,7- dimethoxy- 1H- benzoimidazol- 2- yl)propyl)methylamino)ethyl)- 5- phenylbicyclo(2.2.2)oct- 5- en- 2- yl ester

an L/T-type calcium channel blocker

Also Known As:

ACT-280778

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzimidazoles: 245
      - isobutyric acid 2-(2-((3-(4,7-dimethoxy-1H-benzoimidazol-2-yl)propyl)methylamino)ethyl)-5-phenylbicyclo(2.2.2)oct-5-en-2-yl ester: 2
Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Bridged-Ring Compounds: 1
      - Bridged Bicyclo Compounds
        isobutyric acid 2-(2-((3-(4,7-dimethoxy-1H-benzoimidazol-2-yl)propyl)methylamino)ethyl)-5-phenylbicyclo(2.2.2)oct-5-en-2-yl ester: 2
Polycyclic Compounds: 6
- Bridged-Ring Compounds: 1
  - Bridged Bicyclo Compounds
    - isobutyric acid 2-(2-((3-(4,7-dimethoxy-1H-benzoimidazol-2-yl)propyl)methylamino)ethyl)-5-phenylbicyclo(2.2.2)oct-5-en-2-yl ester: 2

Experts

1.	Dingemanse, J: 1 article (04/2015)
2.	Klainman, E: 1 article (04/2015)
3.	Kracker, H: 1 article (04/2015)
4.	Mueller, M S: 1 article (04/2015)
5.	Otasevic, P: 1 article (04/2015)
6.	Putnikovic, B: 1 article (04/2015)
7.	Shakeri-Nejad, K: 1 article (04/2015)
8.	Zimlichman, R: 1 article (04/2015)
9.	Dingemanse, Jasper: 1 article (02/2014)
10.	Gutierrez, Marcelo M: 1 article (02/2014)

Related Diseases

1.	Hypertension (High Blood Pressure) 02/01/2014 - "Overall, pharmacokinetic and tolerability profiles of ACT-280778 observed in these 2 studies warranted further evaluation of ACT-280778 in a proof-of-concept study in patients with hypertension." 04/01/2015 - "ACT-280778 (10 mg) did not lower blood pressure in mild-to-moderate hypertension. "
2.	Essential Hypertension 04/01/2015 - "Patients with mild-to-moderate essential hypertension received once-daily placebo (n=53), ACT-280778 10 mg (n=52) or amlodipine 10 mg (n=54) for 4 weeks. "

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