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CALAA-01

a targeted, polymer-based nanoparticle containing siRNA

Networked: 3 relevant articles (1 outcomes, 2 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Davis, Mark E: 2 articles (08/2014 - 05/2009)
2.	He, Hongliang: 1 article (01/2019)
3.	Liu, Lisha: 1 article (01/2019)
4.	Liu, Min: 1 article (01/2019)
5.	Morin, Emily E: 1 article (01/2019)
6.	Schwendeman, Anna: 1 article (01/2019)
7.	Chmielowski, Bartosz: 1 article (08/2014)
8.	Gritli, Ismael: 1 article (08/2014)
9.	Heidel, Jeremy D: 1 article (08/2014)
10.	Lim, Dean: 1 article (08/2014)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2019 - "In some cases, findings from these trials have not only shown improved pharmacokinetics, but also avid drug accumulation within tumor tissues among active-targeting nanoparticles, including BIND-014, CALAA-01, and SGT-94. " 08/05/2014 - "Here, we report the results from the initial phase I clinical trial where 24 patients with different cancers were treated with CALAA-01 and compare those results to data obtained from multispecies animal studies to provide a detailed example of translating this class of nanoparticles from animals to humans. " 08/05/2014 - "CALAA-01 is a targeted, polymer-based nanoparticle containing small interfering RNA (siRNA) and, to our knowledge, was the first RNA interference (RNAi)-based, experimental therapeutic to be administered to cancer patients. " 05/01/2009 - "This targeted, nanoparticle formulation of siRNA, denoted as CALAA-01, consists of a cyclodextrin-containing polymer (CDP), a polythethylene glycol (PEG) steric stabilization agent, and human transferrin (Tf) as a targeting ligand for binding to transferrin receptors (TfR) that are typically upregulated on cancer cells. "
2.	Body Weight (Weight, Body) 08/05/2014 - "The pharmacokinetics of CALAA-01 in mice, rats, monkeys, and humans show fast elimination and reveal that the maximum concentration obtained in the blood after i.v. administration correlates with body weight across all species. "

Related Drugs and Biologics

1.	Small Interfering RNA (siRNA)
2.	Polymers
3.	Transferrin (beta 2 Transferrin)
4.	Transferrin Receptors (Transferrin Receptor)
5.	Ligands
6.	Cytidine Diphosphate (CDP)
7.	Cyclodextrins