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(4- methoxy- 1- naphthalenyl)(1- pentyl- 1H- indol- 3- yl)methanone

a street drug component (of spice/K2 preparations) that functions as a cannabinoid receptor 1 ligand; structure in first source

Also Known As:

JWH-081

Networked: 3 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - (4-methoxy-1-naphthalenyl)(1-pentyl-1H-indol-3-yl)methanone: 3
Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Naphthalenes: 18
        (4-methoxy-1-naphthalenyl)(1-pentyl-1H-indol-3-yl)methanone: 3
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Naphthalenes: 18
    - (4-methoxy-1-naphthalenyl)(1-pentyl-1H-indol-3-yl)methanone: 3

Experts

1.	Cha, Hye Jin: 1 article (11/2015)
2.	Han, Kyoungmoon: 1 article (11/2015)
3.	Jeong, Ho-Sang: 1 article (11/2015)
4.	Kang, Hoil: 1 article (11/2015)
5.	Kim, Hyoung Soo: 1 article (11/2015)
6.	Kim, Young-Hoon: 1 article (11/2015)
7.	Seong, Yeon-Hee: 1 article (11/2015)
8.	Shin, Jisoon: 1 article (11/2015)
9.	Song, Min-Ji: 1 article (11/2015)
10.	Yun, Jaesuk: 1 article (11/2015)

Related Diseases

1.	Cognitive Dysfunction 10/01/2013 - "Synthetic cannabinoid testing was performed by LC-MS-MS. Positive results included: JWH-018 (n = 4), 0.1-1.1 ng/mL; JWH-081 (n = 2) qualitative only; JWH-122 (n = 3), 2.5 ng/mL; JWH-210 (n = 4), 0.1 ng/mL; JWH-250 (n = 1), 0.38 ng/mL and AM-2201 (n = 6), 0.43-4.0 ng/mL. While there is good evidence of psychophysical impairment in these subjects, further structured data collection is needed to fully assess the relationship between synthetic cannabinoid use and psychomotor and cognitive impairment. "
2.	Tremor (Tremors) 11/01/2015 - "In functional observation battery (FOB) test, animals treated with 5 mg/kg of JWH-081 or JWH-210 showed traction and tremor. "
3.	Memory Disorders (Memory Loss) 02/01/2014 - "CB1 receptor-mediated signaling underlies the hippocampal synaptic, learning, and memory deficits following treatment with JWH-081, a new component of spice/K2 preparations."

Related Drugs and Biologics

1.	4- ethylnaphthalen- 1- yl- (1- pentylindol- 3- yl)methanone
2.	Cannabinoids
3.	(4- methyl- 1- naphthyl)- (1- pentylindol- 3- yl)methanone
4.	1-(5-fluoropentyl)-3-(1-naphthoyl)indole
5.	1-(1- pentyl- 1H- indol- 3- yl)- 2- (2- methoxyphenyl)ethanone
6.	1-pentyl-3-(1-naphthoyl)indole
7.	CB1 Cannabinoid Receptor (CB1 Receptor)

Related Therapies and Procedures

1.	Traction