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1- (4- (3- (hydroxyimino)- 3- (2- methylpyridin- 4- yl)- 1- o- tolylpropyl)phenyl)piperidine- 4- carboxylic acid

an agonist of G protein-coupled bile acid receptor 1 (GPBAR1); structure in first source

Also Known As:

RO5527239

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperidines: 17
    - Isonipecotic Acids: 1
      - 1-(4-(3-(hydroxyimino)-3-(2-methylpyridin-4-yl)-1-o-tolylpropyl)phenyl)piperidine-4-carboxylic acid: 1
- Heterocyclic Acids
  - Isonipecotic Acids: 1
    - 1-(4-(3-(hydroxyimino)-3-(2-methylpyridin-4-yl)-1-o-tolylpropyl)phenyl)piperidine-4-carboxylic acid: 1
Organic Chemicals: 133
- Amines: 4871
  - Hydroxylamines: 16
    - Oximes: 1292
      - 1-(4-(3-(hydroxyimino)-3-(2-methylpyridin-4-yl)-1-o-tolylpropyl)phenyl)piperidine-4-carboxylic acid: 1

Experts

1.	Adorini, Luciano: 1 article (06/2022)
2.	Gillard, Justine: 1 article (06/2022)
3.	Leclercq, Isabelle A: 1 article (06/2022)
4.	Picalausa, Corinne: 1 article (06/2022)
5.	Staels, Bart: 1 article (06/2022)
6.	Tailleux, Anne: 1 article (06/2022)
7.	Ullmer, Christoph: 1 article (06/2022)

Related Diseases

1.	Metabolic Diseases (Metabolic Disease) 06/29/2022 - "As TGR5 agonism is low in MAFLD, we used strategies to promote the production of endogenous TGR5 ligands or administered pharmacological TGR5 agonists, INT-777 and RO5527239, to study the effect of TGR5 activation on liver and metabolic diseases in high-fat diet-fed foz/foz mice. "
2.	Liver Diseases (Liver Disease) 06/29/2022 - "In spite of the TGR5 activation capacity, INT-777, but not RO5527239, reduced liver disease severity. "

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