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PF-3450074

an anti-HIV agent that binds capsid protein; structure in first source

Also Known As:

PF74 compound

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - PF-3450074: 2
Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - Essential Amino Acids: 1152
    - Phenylalanine: 4090
      - PF-3450074: 2
  - Cyclic Amino Acids: 3
    - Aromatic Amino Acids: 467
      - Phenylalanine: 4090
        PF-3450074: 2

Experts

1.	Alam, Steven L: 1 article (12/2014)
2.	Bhattacharya, Akash: 1 article (12/2014)
3.	Demeler, Borries: 1 article (12/2014)
4.	Diaz-Griffero, Felipe: 1 article (12/2014)
5.	Fricke, Thomas: 1 article (12/2014)
6.	Ganser-Pornillos, Barbie K: 1 article (12/2014)
7.	Ivanov, Dmitri N: 1 article (12/2014)
8.	Pornillos, Owen: 1 article (12/2014)
9.	Sedzicki, Jaroslaw: 1 article (12/2014)
10.	Taylor, Alexander B: 1 article (12/2014)

Related Diseases

1.

01/01/2011 - "We describe here the mechanism of action of a small molecule HIV-1 inhibitor, PF-3450074 (PF74), which targets CA. PF74 acts at an early stage of HIV-1 infection and inhibits reverse transcription in target cells. "
12/30/2014 - "Here we report biochemical experiments showing that PF-3450074 (PF74), a drug that inhibits HIV-1 infection, as well as host proteins cleavage and polyadenylation specific factor 6 (CPSF6) and nucleoporin 153 kDa (NUP153), bind to the CA hexamer with at least 10-fold higher affinities compared with nonassembled CA or isolated CA domains. "

Related Drugs and Biologics

1.	Nuclear Pore Complex Proteins (Nucleoporins)
2.	Proteins (Proteins, Gene)