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3- amino- 3- (4- fluorophenyl)- 1H- quinoline- 2,4- dione

protects against cisplatin-induced auditory cell death; structure in first source

Also Known As:

KR-22332; KR-22335

Networked: 2 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinolines: 146
      - Quinolones: 2938
        3-amino-3-(4-fluorophenyl)-1H-quinoline-2,4-dione: 2

Experts

1.	Hwang, Hye Sook: 1 article (02/2014)
2.	Jung, Young-Sik: 1 article (02/2014)
3.	Kang, Sungun: 1 article (02/2014)
4.	Kim, Chul-Ho: 1 article (02/2014)
5.	Shin, Yoo Seob: 1 article (02/2014)
6.	Song, Suk Jin: 1 article (02/2014)
7.	Choi, J W: 1 article (03/2013)
8.	Hwang, H S: 1 article (03/2013)
9.	Jung, Y-S: 1 article (03/2013)
10.	Kang, S U: 1 article (03/2013)

Related Diseases

1.	Hearing Loss (Hearing Impairment) 03/01/2013 - "Transtympanic administration of KR-22332 in a rat model was protective against cisplatin-induced hearing loss, as determined by click-evoked auditory brainstem response (p<0.01). "
2.	Mitochondrial Diseases (Mitochondrial Disease) 02/01/2014 - "The results of this study suggest that KR-22335 may prevent ototoxicity caused by the administration of cisplatin through the inhibition of mitochondrial dysfunction and suppression of ROS generation. " 03/01/2013 - "The results of this study suggest that KR-22332 may prevent ototoxicity caused by the administration of cisplatin through the inhibition of mitochondrial dysfunction and the suppression of ROS generation. "
3.	Ototoxicity 02/01/2014 - "The results of this study suggest that KR-22335 may prevent ototoxicity caused by the administration of cisplatin through the inhibition of mitochondrial dysfunction and suppression of ROS generation. " 03/01/2013 - "The results of this study suggest that KR-22332 may prevent ototoxicity caused by the administration of cisplatin through the inhibition of mitochondrial dysfunction and the suppression of ROS generation. " 02/01/2014 - "KR-22335 may be considered as a potential candidate for protective agents against cisplatin-induced ototoxicity." 03/01/2013 - "These novel findings implicate KR-22332 as a potential candidate for protective agent against cisplatin-induced ototoxicity. "

Related Drugs and Biologics

1.	Cisplatin (Platino)
2.	Protective Agents

Related Therapies and Procedures

1.	Intratympanic Injection