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5- ((benzyloxy)methyl)- 7- (pyrrolidin- 1- ylmethyl)quinolin- 8- ol

an apoptosis protein inhibitor

Also Known As:

UC-112

Networked: 2 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrrolidines: 115
    - 5-((benzyloxy)methyl)-7-(pyrrolidin-1-ylmethyl)quinolin-8-ol: 2
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinolines: 146
      - Hydroxyquinolines: 9
        5-((benzyloxy)methyl)-7-(pyrrolidin-1-ylmethyl)quinolin-8-ol: 2

Experts

1.	Li, Wei: 2 articles (01/2015 - 05/2014)
2.	Wang, Jin: 2 articles (01/2015 - 05/2014)
3.	Li, Zhenmei: 1 article (01/2015)
4.	Lin, Zongtao: 1 article (01/2015)
5.	Lu, Yan: 1 article (01/2015)
6.	Miller, Duane D: 1 article (01/2015)
7.	White, Stephen W: 1 article (01/2015)
8.	Xiao, Min: 1 article (01/2015)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2015 - "The best three compounds among them along with UC-112 were submitted for NCI-60 cancer cell line screening. " 05/01/2014 - "As a single agent, UC-112 strongly inhibits tumor growth and reduces both X chromosome-linked IAP and survivin levels in an A375 human melanoma xenograft model in vivo. " 01/01/2015 - "The results indicated that structural modification from UC-112 to our best compound 4g has improved activity by four folds (2.2 μM for UC-112 vs. 0.5 μM for 4g, average GI50 values over all cancer cell lines in the NCI-60 panel).Western blot analyses demonstrated the new compounds maintained high selectivity for survivin inhibition over other members in the inhibition of apoptosis protein family. " 05/01/2014 - "UC-112 also potently inhibits the growth of P-glycoprotein (P-gp)-overexpressed multidrug-resistant cancer cells, strongly activates caspase-3/7 and caspase-9 activities, and selectively downregulates survivin level at a concentration as low as 1 µM. "
2.	Melanoma (Melanoma, Malignant) 05/01/2014 - "As a single agent, UC-112 strongly inhibits tumor growth and reduces both X chromosome-linked IAP and survivin levels in an A375 human melanoma xenograft model in vivo. "

Related Drugs and Biologics

1.	Survivin
2.	Proteins (Proteins, Gene)
3.	Caspase 9
4.	Caspase 3 (Caspase-3)
5.	Member 1 Subfamily B ATP Binding Cassette Transporter