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N- (4- chlorophenyl)- 1- ((3- (furan- 2- yl)phenyl)carbonyl)piperidine- 3- carboxamide

inhibits expression of connective tissue growth factor (CTGF), alpha-smooth muscle actin (alpha-SMA), and collagen 1 (COL1A2)

Also Known As:

CCG-203971

Networked: 6 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperidines: 17
    - Nipecotic Acids
      - N-(4-chlorophenyl)-1-((3-(furan-2-yl)phenyl)carbonyl)piperidine-3-carboxamide: 6
- Heterocyclic Acids
  - Nipecotic Acids
    - N-(4-chlorophenyl)-1-((3-(furan-2-yl)phenyl)carbonyl)piperidine-3-carboxamide: 6

Experts

1.	Larsen, Scott D: 4 articles (06/2017 - 04/2015)
2.	Neubig, Richard R: 4 articles (06/2017 - 04/2015)
3.	Higgins, Peter D R: 2 articles (06/2017 - 04/2015)
4.	Rodansky, Eva S: 2 articles (06/2017 - 04/2015)
5.	Lisabeth, Erika M: 2 articles (01/2017 - 01/2017)
6.	Ishii, Masaru: 1 article (01/2020)
7.	Kikuta, Junichi: 1 article (01/2020)
8.	Mizuno, Hiroki: 1 article (01/2020)
9.	Morimatsu, Maho: 1 article (01/2020)
10.	Motooka, Daisuke: 1 article (01/2020)

Related Diseases

1.	Fibrosis (Cirrhosis) 06/01/2017 - "As proof-of-concept, we tested the utility of the SL1344:CBA/J fibrosis model to evaluate efficacy of CCG-203971, a novel anti-fibrotic drug. " 04/01/2015 - "We hypothesized that the SRF/MRTF pathway inhibitor CCG-203971 would modulate myofibroblast function in vitro and limit lung fibrosis in vivo. " 04/01/2015 - "In vivo studies examined the effect of therapeutically administered CCG-203971 on lung fibrosis in two distinct murine models of fibrosis induced by bleomycin or targeted type II alveolar epithelial injury. " 01/01/2017 - "Local delivery of CCG-222740 and CCG-203971 in a validated and clinically relevant rabbit model of scar tissue formation after glaucoma filtration surgery increased the long-term success of the surgery by 67% (P < 0.0005) and 33% (P < 0.01), respectively, and significantly decreased fibrosis and scarring histologically. "
2.	Idiopathic Pulmonary Fibrosis 04/01/2015 - "In vitro, CCG-203971 prevented nuclear localization of MRTF-A; increased the apoptotic susceptibility of normal and idiopathic pulmonary fibrosis fibroblasts; blocked TGF-β1-induced myofibroblast differentiation; and inhibited TGF-β1-induced expression of fibronectin, X-linked inhibitor of apoptosis, and plasminogen activator inhibitor-1. " 04/01/2015 - "Normal and idiopathic pulmonary fibrosis lung fibroblasts were treated with/without CCG-203971 (N-[4-chlorophenyl]-1-[3-(2-furanyl)benzoyl]-3-piperidine carboxamide) and/or Fas-activating antibody in the presence/absence of transforming growth factor (TGF)-β1, and apoptosis was assessed. "
3.	Neoplasms (Cancer) 01/01/2020 - "MRTF inhibition using CCG-203971 augmented the anti-tumor effects of chemotherapy in our AML mouse model, as well as suppressed the migration of chemoresistant C1498 cells. "
4.	Melanoma (Melanoma, Malignant) 01/01/2017 - "To probe the dependence of melanoma aggressiveness to MRTF transcription, we use a previously developed small-molecule inhibitor, CCG-203971, which at low micromolar concentrations blocks nuclear localization and activity of MRTF-A. "
5.	Liver Cirrhosis (Hepatic Cirrhosis) 01/01/2020 - "Finally, there was no effect of CCG-203971 on markers of inflammation, suggesting a direct effect of the compound on HSCs and liver fibrosis. " 01/01/2020 - "Targeting myocardin and MRTF-A binding and function with a novel small molecule, CCG-203971, led to dose-dependent inhibition of HSC actin cytoskeleton dynamics and abrogated multiple functional features of HSC activation (i.e., HSC contraction, migration and proliferation) and decreased COL.1 expression in vitro and liver fibrosis in vivo. "

Related Drugs and Biologics

1.	Bleomycin (Blenoxane)
2.	Transforming Growth Factors (Transforming Growth Factor)
3.	Plasminogen Activators (Plasminogen Activator)
4.	Fibronectins (Fibronectin)
5.	myocardin
6.	piperidine

Related Therapies and Procedures

1.	Filtering Surgery
2.	Drug Therapy (Chemotherapy)