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WJ1398-1

has antineoplastic activity; structure in first source

Networked: 2 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Huang, Wei-Jan: 2 articles (06/2014 - 11/2013)
2.	Liang, Yu-Chih: 2 articles (06/2014 - 11/2013)
3.	Lin, Ren-Jye: 2 articles (06/2014 - 11/2013)
4.	Lin, Shyr-Yi: 2 articles (06/2014 - 11/2013)
5.	Liu, Ling-Yu: 2 articles (06/2014 - 11/2013)
6.	Ho, Feng-Ming: 1 article (06/2014)
7.	Suk, Fat-Moon: 1 article (06/2014)

Related Diseases

1.	Colonic Neoplasms (Colon Cancer) 11/18/2013 - "A series of osthole derivatives have been synthesized, and the N-hydroxycinnamide derivatives of osthole, WJ1376-1 and WJ1398-1 were found to have the greatest potential against human colon adenocarcinoma cells. " 11/18/2013 - "Taken together, these results suggest that the toxic activities of WJ1376-1 and WJ1398-1 were dissimilar to that of the parental osthole, which can induce cell polyploidy and G2/M cell cycle arrest in colon adenocarcinoma cells and may provide a potential therapeutic target for colon cancer treatment in the future. "
2.	Colorectal Neoplasms (Colorectal Cancer) 06/25/2014 - "In this study, we determined that WJ1376-1 and WJ1398-1 strongly inhibited the migration and invasion in human colorectal cancer cells at concentrations as low as 1μM. "
3.	Ataxia Telangiectasia (Louis Bar Syndrome) 06/25/2014 - "Previously, we reported that WJ1376-1 and WJ1398-1 can induce cell-cycle arrest by activating ATR kinase (ataxia telangiectasia and rad3 related kinase) and inhibiting the phosphorylation of Aurora A kinase. " 11/18/2013 - "WJ1376-1 and WJ1398-1 significantly activated ataxia telangiectasia and rad3 related (ATR) kinase, which triggered activation of the checkpoint kinase 2 (Chk2) signaling pathway and then down regulated Cdc25 phosphatase and Cdc2/cyclin B kinase activities. "
4.	Polyploidy 11/18/2013 - "In contrast to the parental osthole, both WJ1376-1 and WJ1398-1 were found to induce multinucleation and polyploidy by microscopic observation and flow cytometry. " 11/18/2013 - "Taken together, these results suggest that the toxic activities of WJ1376-1 and WJ1398-1 were dissimilar to that of the parental osthole, which can induce cell polyploidy and G2/M cell cycle arrest in colon adenocarcinoma cells and may provide a potential therapeutic target for colon cancer treatment in the future. "
5.	Neoplasms (Cancer) 11/18/2013 - "WJ1376-1 and WJ1398-1 ultimately induced apoptosis as evidenced by the upregulation of Bad and activation of caspases-3, -7, and -9. Furthermore, WJ1376-1 and WJ1398-1 also showed a great effect in attenuating tumor growth without affecting the body weight of xenograft nude mice. "

Related Drugs and Biologics

1.	WJ1376-1
2.	osthol (osthole)
3.	Phosphotransferases (Kinase)
4.	Checkpoint Kinase 2
5.	Aurora Kinase A
6.	cdc25 Phosphatases
7.	Cyclin B