5- ethoxycarbonyl- 6- methyl- 4- (4- N,N- dimethylaminophenyl)- 3,4- dihydropyrimidin- 2- (1H)- thione
inhibits ecto-5'-nucleotidase; structure in first source
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Bio-Agent Context: Research Results
Experts
Related Diseases
| 1. | Glioma (Gliomas)
04/01/2014
- " Treatment with LaSOM 63 reduces glioma cell viability and cell growth. " 04/01/2014
- " We describe the effect of LaSOM 63, a monastrol derivative, on ecto-5'NT activity and on glioma cell survival. " 04/01/2014
- " In contrast to monastrol, LaSOM 63 did not cause glioma cell-cycle arrest, but inhibited ecto-5'NT enzyme activity. " 04/01/2014
- " A monastrol-derived compound, LaSOM 63, inhibits ecto-5'nucleotidase/CD73 activity and induces apoptotic cell death of glioma cell lines." 04/01/2014
- " Glioma cells were treated with LaSOM 63 and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), trypan blue assay (viability), flow cytometry (cell cycle/cell death) and malachite green method for ecto-5'NT activity were carried out. "
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