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Secretory Phospholipases A2 Summary

Description: A subcategory of phospholipases A2 that are secreted from cells. They are 14 kDa proteins containing multiple disulfide-bonds and access their substrate via an interfacial binding site that interacts with phospholipid membranes. In addition specific PHOSPHOLIPASE A2 RECEPTORS can bind to and internalize the enzymes.

Also Known As: Phospholipases A2, Secretory; Phospholipases A2, Secreted; SPLA2 Phospholipases; Secreted Phospholipases A2; Secretory Phospholipase A2 Show All >>

Networked: 394 relevant articles (13 outcomes, 62 trials/studies) for this Bio-Agent

Key Diseases for which Secretory Phospholipases A2 is Relevant

  1. Myocardial Infarction : 3 outcomes 1 study in 9 results
  2. Inflammation : 2 outcomes 6 studies in 92 results
  3. Rheumatoid Arthritis : 2 outcomes 1 study in 13 results
  4. Prostatic Neoplasms (Prostate Cancer) : 1 outcome 2 studies in 3 results
  5. Asthma (Bronchial Asthma) : 1 outcome 1 study in 19 results
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Drugs Related to Secretory Phospholipases A2

  1. C-Reactive Protein
  2. Peroxidase (Myeloperoxidase)
  3. 1-Alkyl-2-acetylglycerophosphocholine Esterase (PAF Acetylhydrolase)
  4. varespladib
  5. Lipoproteins (Lipoprotein)
  6. Cytokines
  7. Phospholipases A2 (Phospholipase A2)
  8. Sulfasalazine (Azulfidine)
  9. Lipoxygenase (Lipoxygenase-1)
  10. Eicosanoids
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Therapies Related to Secretory Phospholipases A2

  1. Transplants (Transplant)
  2. Catheters
  3. Liver Transplantation
  4. Neonatal Intensive Care
  5. Myocardial Revascularization
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