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Malformations of Cortical Development Summary

Description: Abnormalities in the development of the CEREBRAL CORTEX. These include malformations arising from abnormal neuronal CELL PROLIFERATION or APOPTOSIS; abnormal neuronal migration; and abnormal establishment of cortical organization via neurite extension, synaptogenesis, or neuronal maturation. As well as mutations effecting these developmental processes directly, there are a variety of inborn metabolic errors, such as PEROXISOMAL DISORDERS and mitochondrial and pyruvate metabolic disorders which effect them secondarily and also exhibit these malformations. They are common causes of EPILEPSY and developmental delay and are often a component of multiple congenital anomalies.

Also Known As: Cerebral Cortical Dysplasia; Cortical Dysplasia; Cortical Dysplasia, Cerebral; Hemimegalencephaly; Malformations of Cerebral Cortex Development Show All >>

Networked: 599 relevant articles (10 outcomes, 53 trials/studies) for this Disease

Key Drugs and Agents for Malformations of Cortical Development

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. 2,6-dinitrotoluene (DNT) : 1 outcome 2 studies in 15 results : IBA
  2. Tryptophan (L-Tryptophan) : 1 outcome 1 study in 2 results : FDA 30
  3. Lennox-Gastaut type Epileptic encephalopathy : 1 outcome in 7 results : IBA
  4. mitomycin C-dextran : 1 outcome in 3 results : IBA
  5. sulthiame (sultiam) : 1 outcome in 1 result : IBA
  6. Proteins (Proteins, Gene) : 4 studies in 14 results : IBA
  7. Glutamate Receptors (Glutamate Receptor) : 3 studies in 6 results : IBA
  8. alpha- Amino- 3- hydroxy- 5- methyl- 4- isoxazolepropionic Acid (AMPA) : 3 studies in 3 results : IBA
  9. Perisylvian syndrome : 2 studies in 27 results : IBA
  10. Tubulin : 2 studies in 14 results : IBA
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Diseases Related to Malformations of Cortical Development

  1. Seizures (Seizure)
  2. Epilepsy (Aura)
  3. Tuberous Sclerosis (Bourneville's Disease)
  4. Neuroepithelial Neoplasms (Gliomatosis Cerebri)
  5. Sturge-Weber Syndrome (Sturge-Kalischer-Weber Syndrome)
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Key Therapies for Malformations of Cortical Development

Efficacy Chart >>
  1. Hemispherectomy : 5 outcomes 2 studies in 41 results
  2. Electrodes (Electrode) : 1 study in 20 results
  3. Anterior Temporal Lobectomy : 1 study in 3 results
  4. Vagus Nerve Stimulation : 1 study in 2 results
  5. Wound Closure Techniques : 1 study in 1 result
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