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KATP Channels Summary

Description: Heteromultimers of Kir6 channels (the pore portion) and sulfonylurea receptor (the regulatory portion) which affect function of the HEART; PANCREATIC BETA CELLS; and KIDNEY COLLECTING DUCTS. KATP channel blockers include GLIBENCLAMIDE and mitiglinide whereas openers include CROMAKALIM and minoxidil sulfate.

Also Known As: ATP Sensitive Potassium Channels; Channels, ATP-Sensitive Potassium; Channels, KATP; Potassium Channels, ATP-Sensitive; ATP-Sensitive Potassium Channels

Networked: 541 relevant articles (13 outcomes, 56 trials/studies) for this Bio-Agent

Key Diseases for which KATP Channels is Relevant

  1. Reperfusion Injury : 4 outcomes 2 studies in 29 results
  2. Ischemia : 2 outcomes 9 studies in 108 results
  3. Myocardial Ischemia (Ischemic Heart Diseases) : 2 outcomes 4 studies in 33 results
  4. Anoxia (Hypoxia) : 1 outcome 11 studies in 103 results
  5. Hypertension (High Blood Pressure) : 1 outcome 1 study in 11 results
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Drugs Related to KATP Channels

  1. Adenosine Triphosphate (ATP)
  2. Potassium
  3. Pinacidil (Pindac)
  4. Glyburide (Glibenclamide)
  5. Hydrogen Sulfide (Sulfide, Hydrogen)
  6. Insulin (Novolin)
  7. mitochondrial K(ATP) channel
  8. Hydroxyl Radical
  9. Diosgenin
  10. Adenosine
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Therapies Related to KATP Channels

  1. Induced Heart Arrest (Cardioplegia)
  2. Angioplasty (Angioplasty, Transluminal)
  3. Decompression
  4. Catheters
  5. Therapeutics
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