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Lissencephaly Summary

Description: A "smooth brain" malformation of the CEREBRAL CORTEX resulting from abnormal location of developing neurons during corticogenesis. It is characterized by an absence of normal convoluted indentations on the surface of the brain (agyria), or fewer and shallower indentations (pachygryia). There is a reduced number of cortical layers, typically 4 instead of 6, resulting in a thickened cortex, and reduced cerebral white matter that is a reversal of the normal ratio of cerebral white matter to cortex.

Also Known As: Lissencephalia; Agyrias; Lissencephalias; Lissencephalies; Pachygyrias Show All >>

Networked: 234 relevant articles (0 outcomes, 10 trials/studies) for this Disease

Key Drugs and Agents for Lissencephaly

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. DNA (Deoxyribonucleic Acid) : 3 studies in 9 results : IBA
  2. Dyneins (Dynein) : 2 studies in 28 results : IBA
  3. Platelet Activating Factor : 1 study in 12 results : IBA
  4. Double cortex : 1 study in 11 results : IBA
  5. Technetium Tc 99m Exametazime (Ceretec) : 1 study in 2 results : FDA 1
  6. Collagen : 1 study in 2 results : IBA
  7. Diethylhexyl Phthalate (DEHP) : 1 study in 1 result : IBA
  8. Tubulin : 14 results : IBA
  9. Retinaldehyde (Retinal) : 13 results : IBA
  10. Colpocephaly : 12 results : IBA
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Diseases Related to Lissencephaly

  1. Lissencephaly
  2. Malformations of Cortical Development
  3. Tuberous Sclerosis (Bourneville's Disease)
  4. Congenital Abnormalities (Deformity)
  5. Spinal Muscular Atrophy (Progressive Muscular Atrophy)
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Key Therapies for Lissencephaly

Efficacy Chart >>
  1. Sutures (Suture) : 1 result
  2. Ligation : 1 result
  3. Intraperitoneal Injections : 1 result

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