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Dihydropyrimidine Dehydrogenase Deficiency Summary

Description: An autosomal recessive disorder affecting DIHYDROPYRIMIDINE DEHYDROGENASE and causing familial pyrimidinemia. It is characterized by thymine-uraciluria in homozygous deficient patients. Even a partial deficiency in the enzyme leaves individuals at risk for developing severe 5-FLUOROURACIL-associated toxicity.

Also Known As: Dihydropyrimidinuria; Familial Pyrimidinemia; Thymine-Uraciluria, Hereditary; Deficiencies, Dihydropyrimidine Dehydrogenase; Deficiency, Dihydropyrimidine Dehydrogenase Show All >>

Networked: 68 relevant articles (0 outcomes, 1 trials/studies) for this Disease

Key Drugs and Agents for Dihydropyrimidine Dehydrogenase Deficiency

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Fluorouracil (Carac) : 1 study in 29 results : FDA 33 Generic
  2. Uracil : 9 results : IBA
  3. Thymine : 8 results : IBA
  4. pyrimidine : 8 results : IBA
  5. dihydropyrimidinase : 8 results : IBA
  6. capecitabine (Xeloda) : 6 results : FDA 1
  7. Adenylosuccinate lyase deficiency : 4 results : IBA
  8. dihydrouracil : 4 results : IBA
  9. Biological Markers (Surrogate Marker) : 2 results : IBA
  10. Thymidine : 2 results : IBA
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Diseases Related to Dihydropyrimidine Dehydrogenase Deficiency

  1. Dihydropyrimidine Dehydrogenase Deficiency
  2. Colorectal Neoplasms (Colorectal Cancer)
  3. Leukoencephalopathies
  4. Ornithine Carbamoyltransferase Deficiency Disease
  5. Anaplastic Large-Cell Lymphoma (Ki 1 Lymphoma)
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Key Therapies for Dihydropyrimidine Dehydrogenase Deficiency

Efficacy Chart >>
  1. Drug Therapy (Chemotherapy) : 5 results
  2. Adjuvant Chemotherapy : 3 results
  3. Aftercare (After-Treatment) : 1 result

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