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Brugada Syndrome Summary

Description: An autosomal dominant defect of cardiac conduction that is characterized by an abnormal ST-segment in leads V1-V3 on the ELECTROCARDIOGRAM resembling a right BUNDLE-BRANCH BLOCK; high risk of VENTRICULAR TACHYCARDIA; or VENTRICULAR FIBRILLATION; SYNCOPAL EPISODE; and possible sudden death. This syndrome is linked to mutations of gene encoding the cardiac SODIUM CHANNEL alpha subunit.

Also Known As: Brugada ECG Pattern; Brugada Type ECG Pattern; Sudden Unexplained Nocturnal Death Syndrome (SUNDS); ECG Pattern, Brugada

Networked: 827 relevant articles (21 outcomes, 56 trials/studies) for this Disease

Key Drugs and Agents for Brugada Syndrome

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Quinidine (Chinidin) : 8 outcomes 4 studies in 38 results : FDA 49 Generic
  2. Paroxysmal ventricular fibrillation : 3 outcomes 5 studies in 71 results : IBA
  3. Anti-Arrhythmia Agents : 2 outcomes 2 studies in 21 results : IBA
  4. Disopyramide (Norpace) : 2 outcomes 1 study in 2 results : FDA 21 Generic
  5. Ajmaline (Wolfina) : 1 outcome 6 studies in 62 results : FDA 1
  6. Sodium Channels (Sodium Channel) : 1 outcome 4 studies in 172 results : IBA
  7. Ion Channels (Ion Channel) : 1 outcome 2 studies in 55 results : IBA
  8. Bepridil (Vascor) : 1 outcome 1 study in 2 results : FDA 2
  9. Sodium Channel Blockers (Potassium Sparing Diuretics) : 1 outcome in 17 results : IBA
  10. Sugammadex : 1 outcome in 4 results : IBA
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Diseases Related to Brugada Syndrome

  1. Ventricular Fibrillation
  2. Sudden Death
  3. Ventricular Tachycardia
  4. Shock
  5. Pain (Aches)
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Key Therapies for Brugada Syndrome

Efficacy Chart >>
  1. Implantable Defibrillators (Implantable Cardioverter-Defibrillator) : 4 outcomes 10 studies in 84 results
  2. Defibrillators (Defibrillator) : 3 outcomes 4 studies in 33 results
  3. Drug Therapy (Chemotherapy) : 1 outcome 1 study in 8 results
  4. Electric Countershock (Cardioversion) : 1 study in 8 results
  5. Denervation : 1 study in 3 results
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