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Amyloid Precursor Protein Secretases (beta-Secretase) Summary

Description: Endopeptidases that are specific for AMYLOID PROTEIN PRECURSOR. Three secretase subtypes referred to as alpha, beta, and gamma have been identified based upon the region of amyloid protein precursor they cleave.

Also Known As: beta-Secretase; alpha-Secretase; gamma-Secretase; Secretase; APP Secretase; Amyloid Precursor Protein Secretase; Secretases; Secretase, APP; alpha Secretase; beta Secretase; gamma Secretase

Networked: 1948 relevant articles (42 outcomes, 143 trials/studies) for this Bio-Agent

Key Diseases for which Amyloid Precursor Protein Secretases is Relevant

  1. Alzheimer Disease (Alzheimer's Disease) : 17 outcomes 52 studies in 1283 results
  2. Neoplasms (Cancer) : 7 outcomes 18 studies in 139 results
  3. Amyloid Plaque : 4 outcomes 2 studies in 170 results
  4. Stroke (Strokes) : 3 outcomes 2 studies in 14 results
  5. Amyloidosis : 2 outcomes 2 studies in 12 results
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Drugs Related to Amyloid Precursor Protein Secretases

  1. Amyloid (Amyloid Fibrils)
  2. Presenilins
  3. Proteins (Proteins, Gene)
  4. Folic Acid (Vitamin M)
  5. 2'- deoxythymidylyl- (3'- 5')- 2'- deoxyadenosine (d(AT))
  6. 2,2- dimethyl- N- (6- oxo- 6,7- dihydro- 5H- dibenzo(b,d)azepin- 7- yl)- N'- (2,2,3,3,3- pentafluoropropyl)malonamide
  7. Peptides
  8. N2- ((2S)- 2- (3,5- difluorophenyl)- 2- hydroxyethanoyl)- N1- ((7S)- 5- methyl- 6- oxo- 6,7- dihydro- 5H- dibenzo(b,d)azepin- 7- yl)- L- alaninamide
  9. 2- (5,7- difluoro- 1,2,3,4- tetrahydronaphthalen- 3- ylamino)- N- (1- (2- methyl- 1- (neopentylamino)propan- 2- yl)- 1H- imidazol- 4- yl)pentanamide
  10. Cholesterol
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Therapies Related to Amyloid Precursor Protein Secretases

  1. Heterologous Transplantation (Xenotransplantation)
  2. Cell Transplantation
  3. Immunotherapy
  4. Therapeutics
  5. Drug Therapy (Chemotherapy)
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