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Presenilin-2 Summary

Description: Integral membrane protein of Golgi and endoplasmic reticulum. Its homodimer is an essential component of the gamma-secretase complex that catalyzes the cleavage of membrane proteins such as NOTCH RECEPTORS and AMYLOID BETA-PEPTIDES precursors. PSEN2 mutations cause ALZHEIMER DISEASE type 4.

Also Known As: Presenilin 2

Networked: 246 relevant articles (2 outcomes, 15 trials/studies) for this Bio-Agent

Key Diseases for which Presenilin-2 is Relevant

  1. Alzheimer Disease (Alzheimer's Disease) : 1 outcome 10 studies in 213 results
  2. Cholangiocarcinoma : 1 outcome in 1 result
  3. Neuroblastoma : 1 study in 6 results
  4. Frontotemporal Dementia : 1 study in 2 results
  5. Glioma (Gliomas) : 1 study in 2 results
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Drugs Related to Presenilin-2

  1. Presenilin-1
  2. Amyloid Precursor Protein Secretases (beta-Secretase)
  3. Endocannabinoids (Endocannabinoid)
  4. Amyloid (Amyloid Fibrils)
  5. Messenger RNA (mRNA)
  6. Apolipoproteins
  7. Flavin-Adenine Dinucleotide (FAD)
  8. Proteins (Proteins, Gene)
  9. Presenilins
  10. Amyloid beta-Protein Precursor (Amyloid Protein Precursor)
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Therapies Related to Presenilin-2

  1. Oral Administration

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