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Pachyonychia Congenita (Jadassohn-Lewandowsky Syndrome) Summary

Description: A group of inherited ectodermal dysplasias whose most prominent clinical feature is hypertrophic nail dystrophy resulting in PACHYONYCHIA. Several specific subtypes of pachyonychia congenita have been associated with mutations in genes that encode KERATINS.

Also Known As: Jadassohn-Lewandowsky Syndrome; Pachyonychia Congenita, Jackson-Lawler Type; Jackson-Lawler Type Pachyonychia Congenita; Pachyonychia Congenita Tarda, Type 1; Pachyonychia Congenita, Jadassohn-Lewandowsky Type Show All >>

Networked: 153 relevant articles (4 outcomes, 5 trials/studies) for this Disease

Key Drugs and Agents for Pachyonychia Congenita

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Keratin-6 (Keratin 6A) : 1 outcome in 15 results : IBA
  2. Small Interfering RNA (siRNA) : 1 outcome in 5 results : IBA
  3. Acitretin : 1 outcome in 2 results : FDA 1
  4. Vitamins : 1 outcome in 1 result : IBA
  5. Adenocarcinoma of lung : 1 outcome in 1 result : IBA
  6. gefitinib (Iressa) : 1 outcome in 1 result : FDA 1
  7. Keratins (Keratin) : 1 study in 43 results : IBA
  8. Keratin-17 (Keratin 17) : 1 study in 29 results : IBA
  9. Keratin-16 (Keratin 16) : 1 study in 7 results : IBA
  10. DNA (Deoxyribonucleic Acid) : 1 study in 2 results : IBA
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Diseases Related to Pachyonychia Congenita

  1. Palmoplantar Keratoderma (Keratosis Palmaris et Plantaris)
  2. Epidermal Cyst (Sebaceous Cyst)
  3. Cysts
  4. Pachyonychia Congenita (Jadassohn-Lewandowsky Syndrome)
  5. Ectodermal Dysplasia (Aplasia Cutis Congenita)
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Key Therapies for Pachyonychia Congenita

Efficacy Chart >>
  1. Gas Lasers : 3 results
  2. Electrocoagulation (Electrocautery) : 2 results
  3. Semiconductor Lasers : 1 result
  4. Solid-State Lasers : 1 result
  5. Cryotherapy (Therapy, Cold) : 1 result
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