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Apolipoprotein E4 Summary

Description: A major and the second most common isoform of apolipoprotein E. In humans, Apo E4 differs from APOLIPOPROTEIN E3 at only one residue 112 (cysteine is replaced by arginine), and exhibits a lower resistance to denaturation and greater propensity to form folded intermediates. Apo E4 is a risk factor for ALZHEIMER DISEASE and CARDIOVASCULAR DISEASES.

Also Known As: Apo E epsilon 4; Apo E-4; Apo E4; ApoE4; Apolipoprotein E-4; Apo E 4; Apolipoprotein E 4

Networked: 1016 relevant articles (21 outcomes, 114 trials/studies) for this Bio-Agent

Key Diseases for which Apolipoprotein E4 is Relevant

  1. Alzheimer Disease (Alzheimer's Disease) : 7 outcomes 44 studies in 525 results
  2. Infection : 3 outcomes 1 study in 14 results
  3. Dementia (Dementias) : 2 outcomes 13 studies in 124 results
  4. Atrophy : 2 outcomes 6 studies in 34 results
  5. Atherosclerosis : 2 outcomes 5 studies in 47 results
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Drugs Related to Apolipoprotein E4

  1. Apolipoproteins
  2. Apolipoprotein E4
  3. Apolipoproteins E (ApoE)
  4. Apolipoprotein E3
  5. Cholesterol
  6. Amyloid (Amyloid Fibrils)
  7. Lipoproteins (Lipoprotein)
  8. Peptides
  9. Carbon Monoxide
  10. Apolipoprotein A-I (Apolipoprotein A1)
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Therapies Related to Apolipoprotein E4

  1. Lithotripsy (Extracorporeal Shockwave Lithotripsy)
  2. Transplants (Transplant)
  3. Polypharmacy
  4. Bone Marrow Transplantation (Transplantation, Bone Marrow)
  5. Therapeutics
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