Search Login Register

Variegate Porphyria (Protoporphyrinogen Oxidase Deficiency) Summary

Description: An autosomal dominant porphyria that is due to a deficiency of protoporphyrinogen oxidase (EC 1.3.3.4) in the LIVER, the seventh enzyme in the 8-enzyme biosynthetic pathway of HEME. Clinical features include both neurological symptoms and cutaneous lesions. Patients excrete increased levels of porphyrin precursors, COPROPORPHYRINS and protoporphyrinogen.

Also Known As: Protoporphyrinogen Oxidase Deficiency; Porphyria, Variegate; Porphyria Variegate; Deficiencies, Protoporphyrinogen Oxidase; Porphyria Variegates Show All >>

Networked: 154 relevant articles (2 outcomes, 10 trials/studies) for this Disease

Key Drugs and Agents for Variegate Porphyria

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Heme (Haem) : 1 outcome 2 studies in 33 results : IBA
  2. heme arginate : 1 outcome in 3 results : IBA
  3. coproporphyrin I : 1 outcome in 3 results : IBA
  4. Antipyrine (Phenazone) : 1 outcome in 2 results : FDA 1
  5. Protoporphyrinogen Oxidase (Protox) : 3 studies in 70 results : IBA
  6. Porphyrins : 1 study in 20 results : IBA
  7. Hydroxymethylbilane Synthase (Porphobilinogen Deaminase) : 1 study in 6 results : IBA
  8. Enzymes : 1 study in 5 results : IBA
  9. Nonsense Codon (Nonsense Mutation) : 1 study in 1 result : IBA
  10. Reactive Oxygen Species (Oxygen Radicals) : 1 study in 1 result : IBA
Show All >>

Diseases Related to Variegate Porphyria

  1. Acute Intermittent Porphyria (Porphyria, Acute)
  2. Porphyrias
  3. Hepatic Porphyrias (Hepatic Porphyria)
  4. Nephrotic Syndrome (Syndrome, Nephrotic)
  5. Kidney Diseases (Kidney Disease)
Show All >>

Key Therapies for Variegate Porphyria

Efficacy Chart >>
  1. Renal Dialysis (Hemodialysis) : 1 study in 2 results
  2. Continuous Ambulatory Peritoneal Dialysis (CAPD) : 1 study in 1 result
  3. Anesthesia : 2 results
  4. Transplants (Transplant) : 1 result
  5. Liver Transplantation : 1 result
Show All >>

CureHunter Inc. provides medical information and specifically does NOT provide medical advice.
© Copyright 2003-2016 CureHunter Inc., MeSH copyright NLM, Journal Articles copyright original owners.