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LEOPARD Syndrome (Syndrome, LEOPARD) Summary

Description: An autosomal dominant disorder with an acronym of its seven features (LENTIGO; ELECTROCARDIOGRAM abnormalities; ocular HYPERTELORISM; PULMONARY STENOSIS; abnormal genitalia; retardation of growth; and DEAFNESS or SENSORINEURAL HEARING LOSS). This syndrome is caused by mutations of PTPN11 gene encoding the non-receptor PROTEIN TYROSINE PHOSPHATASE, type 11, and is an allelic to NOONAN SYNDROME. Features of LEOPARD syndrome overlap with those of NEUROFIBROMATOSIS 1 which is caused by mutations in the NEUROFIBROMATOSIS 1 GENES.

Also Known As: Syndrome, LEOPARD; Multiple Lentigines Syndrome; LEOPARD Syndromes; Lentigines Syndrome, Multiple; Lentigines Syndromes, Multiple Show All >>

Networked: 64 relevant articles (0 outcomes, 3 trials/studies) for this Disease

Key Drugs and Agents for LEOPARD Syndrome

Efficacy Chart >>
Drugs and Important Biological Agents (IBA) related to treatments:
  1. Protein Kinases (Protein Kinase) : 1 study in 5 results : IBA
  2. Carbon Monoxide : 1 study in 3 results : IBA
  3. Noonan like syndrome : 1 study in 3 results : IBA
  4. Hormones : 1 study in 1 result : IBA
  5. Cardiofaciocutaneous syndrome : 10 results : IBA
  6. Protein Tyrosine Phosphatases : 7 results : IBA
  7. Legius syndrome : 7 results : IBA
  8. 1 LEOPARD syndrome : 7 results : IBA
  9. Neurofibromatosis-Noonan syndrome : 5 results : IBA
  10. Phosphotransferases (Kinase) : 3 results : IBA
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Diseases Related to LEOPARD Syndrome

  1. Noonan Syndrome (Female Pseudo-Turner Syndrome)
  2. Costello Syndrome
  3. Neurofibromatosis 1 (Neurofibromatosis Type I)
  4. Neurofibromatoses (Neurofibromatosis)
  5. LEOPARD Syndrome (Syndrome, LEOPARD)
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Key Therapies for LEOPARD Syndrome

Efficacy Chart >>
  1. Anesthesia : 2 results
  2. Cochlear Implantation : 1 result
  3. Implantable Defibrillators (Implantable Cardioverter-Defibrillator) : 1 result
  4. General Anesthesia : 1 result

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