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1-Alkyl-2-acetylglycerophosphocholine Esterase (PAF Acetylhydrolase) Summary

Description: A lipoprotein-associated PHOSPHOLIPASE A2 which modulates the action of PLATELET ACTIVATING FACTOR by hydrolyzing the SN-2 ester bond to yield the biologically inactive lyso-platelet-activating factor. It has specificity for phospholipid substrates with short-chain residues at the SN-2 position, but inactive against long-chain phospholipids. Deficiency in this enzyme is associated with many diseases including ASTHMA, and HYPERCHOLESTEROLEMIA.

Also Known As: PAF Acetylhydrolase; Lipoprotein-Associated Phospholipase A(2); Lipoprotein-Associated Phospholipase A2; Lp-PLA(2); Lp-PLA2 Show All >>

Networked: 595 relevant articles (19 outcomes, 142 trials/studies) for this Bio-Agent

Key Diseases for which 1-Alkyl-2-acetylglycerophosphocholine Esterase is Relevant

  1. Stroke (Strokes) : 4 outcomes 25 studies in 75 results
  2. Atherosclerosis : 3 outcomes 35 studies in 160 results
  3. Coronary Disease (Coronary Heart Disease) : 3 outcomes 22 studies in 62 results
  4. Inflammation : 3 outcomes 13 studies in 139 results
  5. Atherosclerotic Plaque (Atheroma) : 3 outcomes 7 studies in 52 results
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Drugs Related to 1-Alkyl-2-acetylglycerophosphocholine Esterase

  1. C-Reactive Protein
  2. Lipoproteins (Lipoprotein)
  3. darapladib
  4. Secretory Phospholipases A2
  5. Apolipoproteins
  6. LDL Cholesterol
  7. Triglycerides (Triacylglycerol)
  8. atorvastatin (Lipitor)
  9. Pravastatin (Pravachol)
  10. Lysophosphatidylcholines (Lysophosphatidylcholine)
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Therapies Related to 1-Alkyl-2-acetylglycerophosphocholine Esterase

  1. Bariatric Surgery
  2. Caloric Restriction
  3. Immunomodulation
  4. Intensive Care (Surgical Intensive Care)
  5. Aftercare (After-Treatment)
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