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Angiopoietin-2 Summary

Description: An angiopoietin that is closely related to ANGIOPOIETIN-1. It binds to the TIE-2 RECEPTOR without receptor stimulation and antagonizes the effect of ANGIOPOIETIN-1. However its antagonistic effect may be limited to cell receptors that occur within the vasculature. Angiopoietin-2 may therefore play a role in down-regulation of BLOOD VESSEL branching and sprouting.

Also Known As: Angiopoietin 2

Networked: 645 relevant articles (7 outcomes, 70 trials/studies) for this Bio-Agent

Key Diseases for which Angiopoietin-2 is Relevant

  1. Neoplasms (Cancer) : 1 outcome 11 studies in 156 results
  2. Inflammation : 1 outcome 2 studies in 48 results
  3. Sepsis (Septicemia) : 1 outcome 2 studies in 30 results
  4. Macular Degeneration (Age-Related Maculopathy) : 1 outcome 1 study in 2 results
  5. Systemic Scleroderma (Systemic Sclerosis) : 1 outcome in 2 results
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Drugs Related to Angiopoietin-2

  1. Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
  2. glucuronyl glucosamine glycan sulfate (Vessel)
  3. Cyclophosphamide (Cytoxan)
  4. Angiopoietin-1
  5. Messenger RNA (mRNA)
  6. TIE-2 Receptor (Receptor, TIE 2)
  7. Biological Markers (Surrogate Marker)
  8. Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)
  9. angiogenin
  10. Proteins (Proteins, Gene)
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Therapies Related to Angiopoietin-2

  1. Heterologous Transplantation (Xenotransplantation)
  2. Transplants (Transplant)
  3. Drug Therapy (Chemotherapy)
  4. Vitrectomy
  5. Homologous Transplantation (Allograft)
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